What's new for 'JKB_daily1' in PubMed

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Sender's message: Sepsis or genomics or altitude: JKB_daily1

Sent on Wednesday, 2010 Mar 10
Search (sepsis[MeSH Terms] OR septic shock[MeSH Terms] OR altitude[MeSH Terms] OR genomics[MeSH Terms] OR genetics[MeSH Terms] OR retrotransposons[MeSH Terms] OR macrophage[MeSH Terms]) AND ("2009/8/8"[Publication Date] : "3000"[Publication Date]) AND (("Science"[Journal] OR "Nature"[Journal] OR "The New England journal of medicine"[Journal] OR "Lancet"[Journal] OR "Nature genetics"[Journal] OR "Nature medicine"[Journal]) OR (Hume DA[Author] OR Baillie JK[Author] OR Faulkner, Geoffrey J[Author]))
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PubMed Results

Items 1 - 6 of 6

1.	N Engl J Med. 2010 Mar 4;362(9):846-50. Collection of data on patients' race and ethnic group by physician practices. Wynia MK, Ivey SL, Hasnain-Wynia R. Institute for Ethics at the American Medical Association, and the University of Chicago, Chicago, USA.
	PMID: 20200391 [PubMed - indexed for MEDLINE]
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	MeSH Terms: Continental Population Groups/statistics & numerical data* Data Collection*/ethics Data Collection*/methods Demography Ethnic Groups/statistics & numerical data* Healthcare Disparities/statistics & numerical data* Humans Pharmacogenetics Physician's Practice Patterns/ethics Physician's Practice Patterns/statistics & numerical data* Physicians United States

2.	Science. 2010 Feb 19;327(5968):1010-3. Peptidomimetic antibiotics target outer-membrane biogenesis in Pseudomonas aeruginosa. Srinivas N, Jetter P, Ueberbacher BJ, Werneburg M, Zerbe K, Steinmann J, Van der Meijden B, Bernardini F, Lederer A, Dias RL, Misson PE, Henze H, Zumbrunn J, Gombert FO, Obrecht D, Hunziker P, Schauer S, Ziegler U, Käch A, Eberl L, Riedel K, DeMarco SJ, Robinson JA. Chemistry Department, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. Antibiotics with new mechanisms of action are urgently required to combat the growing health threat posed by resistant pathogenic microorganisms. We synthesized a family of peptidomimetic antibiotics based on the antimicrobial peptide protegrin I. Several rounds of optimization gave a lead compound that was active in the nanomolar range against Gram-negative Pseudomonas spp., but was largely inactive against other Gram-negative and Gram-positive bacteria. Biochemical and genetic studies showed that the peptidomimetics had a non-membrane-lytic mechanism of action and identified a homolog of the beta-barrel protein LptD (Imp/OstA), which functions in outer-membrane biogenesis, as a cellular target. The peptidomimetic showed potent antimicrobial activity in a mouse septicemia infection model. Drug-resistant strains of Pseudomonas are a serious health problem, so this family of antibiotics may have important therapeutic applications.
	PMID: 20167788 [PubMed - indexed for MEDLINE]
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	Publication Types: Research Support, Non-U.S. Gov't MeSH Terms: Animals Anti-Bacterial Agents/chemical synthesis Anti-Bacterial Agents/metabolism Anti-Bacterial Agents/pharmacology* Antimicrobial Cationic Peptides/chemistry Bacterial Outer Membrane Proteins/chemistry Bacterial Outer Membrane Proteins/genetics Bacterial Outer Membrane Proteins/metabolism* Cell Membrane/metabolism* Drug Design Drug Resistance, Bacterial/genetics Genes, Bacterial Lipopolysaccharides/metabolism Mice Microbial Sensitivity Tests Molecular Mimicry Mutation Peptide Library Peptides/chemical synthesis Peptides/chemistry Peptides/metabolism Peptides/pharmacology* Protein Structure, Tertiary Pseudomonas Infections/drug therapy Pseudomonas Infections/microbiology Pseudomonas aeruginosa/drug effects* Pseudomonas aeruginosa/growth & development Pseudomonas aeruginosa/metabolism* Pseudomonas aeruginosa/ultrastructure Sepsis/drug therapy Sepsis/microbiology Substances: Anti-Bacterial Agents Antimicrobial Cationic Peptides Bacterial Outer Membrane Proteins Lipopolysaccharides Peptide Library Peptides protegrin-1

3.	Science. 2010 Feb 19;327(5968):972. Retrospective. Marshall Warren Nirenberg (1927-2010). Leder P. Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. leder@genetics.med.harvard.edu
	PMID: 20167780 [PubMed - indexed for MEDLINE]
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	Publication Types: Biography Historical Article Portraits MeSH Terms: Genetic Code* History, 20th Century History, 21st Century Molecular Biology/history* National Institutes of Health (U.S.)/history Nobel Prize United States Personal Name as Subject: Nirenberg MW

4.	Lancet. 2010 Feb 6;375(9713):460; author reply 461. Preventable deaths in sickle-cell anaemia in African children. Obaro S. Comment on: Lancet. 2009 Oct 17;374(9698):1364-70.
	PMID: 20152540 [PubMed - indexed for MEDLINE]
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	Publication Types: Comment Letter MeSH Terms: Africa South of the Sahara/epidemiology Anemia, Sickle Cell/complications Anemia, Sickle Cell/microbiology Anemia, Sickle Cell/mortality* Bacteremia/etiology Bacteremia/prevention & control Bacterial Vaccines/therapeutic use Cause of Death Child Humans Neisseria meningitidis/immunology Salmonella Infections/etiology Salmonella Infections/prevention & control* Salmonella typhi/immunology Substances: Bacterial Vaccines

5.	Lancet. 2010 Feb 6;375(9713):460-1; author reply 461. Preventable deaths in sickle-cell anaemia in African children. Murphy RA. Comment on: Lancet. 2009 Oct 17;374(9698):1364-70.
	PMID: 20152539 [PubMed - indexed for MEDLINE]
	Related articles
	Publication Types: Comment Letter MeSH Terms: Anemia, Sickle Cell/complications Anemia, Sickle Cell/microbiology* Anemia, Sickle Cell/mortality Anti-Bacterial Agents/pharmacology* Bacteremia/complications Bacteremia/diagnosis Bacteremia/drug therapy* Child Drug Resistance, Bacterial/drug effects Gram-Negative Bacteria/drug effects* Gram-Negative Bacteria/enzymology Gram-Negative Bacterial Infections/drug therapy Humans Kenya/epidemiology beta-Lactamases/metabolism Substances: Anti-Bacterial Agents beta-Lactamases

6.	Lancet. 2010 Feb 6;375(9713):457; author reply 458-9. Community-based interventions to reduce maternal mortality. Ronsmans C, Huang W. Comment on: Lancet. 2009 Oct 24;374(9699):1441-8.
	PMID: 20152534 [PubMed - indexed for MEDLINE]
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	Publication Types: Comment Letter MeSH Terms: Africa South of the Sahara/epidemiology Community Health Planning/organization & administration* Female Humans Maternal Health Services/organization & administration* Maternal Mortality* Misoprostol/therapeutic use Models, Statistical Oxytocics/therapeutic use Postpartum Hemorrhage/drug therapy Postpartum Hemorrhage/mortality Pregnancy Sepsis/drug therapy Sepsis/mortality Substances: Oxytocics Misoprostol