What's new for 'JKB_daily1' in PubMed

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Sender's message: Sepsis or genomics or altitude: JKB_daily1

Sent on Tuesday, 2010 Oct 05
Search (sepsis[MeSH Terms] OR septic shock[MeSH Terms] OR altitude[MeSH Terms] OR genomics[MeSH Terms] OR genetics[MeSH Terms] OR retrotransposons[MeSH Terms] OR macrophage[MeSH Terms]) AND ("2009/8/8"[Publication Date] : "3000"[Publication Date]) AND (("Science"[Journal] OR "Nature"[Journal] OR "The New England journal of medicine"[Journal] OR "Lancet"[Journal] OR "Nature genetics"[Journal] OR "Nature medicine"[Journal]) OR (Hume DA[Author] OR Baillie JK[Author] OR Faulkner, Geoffrey J[Author]))
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PubMed Results

Items 1 - 6 of 6

1.	Science. 2010 Sep 17;329(5998):1530-4. Bifurcation of Toll-like receptor 9 signaling by adaptor protein 3. Sasai M, Linehan MM, Iwasaki A. Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. Abstract Endosomal Toll-like receptors (TLRs) 7 and 9 recognize viral pathogens and induce signals leading to the activation of nuclear factor κB (NF-κB)-dependent proinflammatory cytokines and interferon regulatory factor 7 (IRF7)-dependent type I interferons (IFNs). Recognition of viral nucleic acids by TLR9 requires its cleavage in the endolysosomal compartment. Here, we show that TLR9 signals leading to the activation of type I IFN, but not proinflammatory cytokine genes, require TLR9 trafficking from endosomes to a specialized lysosome-related organelle. Furthermore, we identify adapter protein-3 as the protein complex responsible for the trafficking of TLR9 to this subcellular compartment. Our results reveal an intracellular mechanism for bifurcation of TLR9 signals by selective receptor trafficking within the endosomal system.
	PMID: 20847273 [PubMed - indexed for MEDLINE]
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2.	Science. 2010 Sep 17;329(5998):1467; author reply 1467-8. Archaeology augments Tibet's genetic history. < a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Brantingham%20PJ%22%5BAuthor%5D">Brantingham PJ, Rhode D, Madsen DB. Comment on: Science. 2010 Jul 2;329(5987):75-8. Science. 2010 Jul 2;329(5987):72-5.
	PMID: 20847252 [PubMed - indexed for MEDLINE]
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3.	Nature. 2010 Aug 12;466(7308):817-8. Which way for genetic-test regulation? Assign regulation appropriate to the level of risk. Javitt G. Berman Institute of Bioethics, Johns Hopkins University, USA. gjavitt1@jhu.edu
	PMID: 20703288 [PubMed - indexed for MEDLINE]
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4.	Nature. 2010 Aug 12;466(7308):816-7. Which way for genetic-test regulation? Leave test interpretation to specialists. Beaudet AL. Department of Molecular and Human Genetics at Baylor College of Medicine, Houston, Texas 77030, USA. abeaudet@bcm.edu Comment in: Nature. 2010 Aug 26;466(7310):1040.
	PMID: 20703287 [PubMed - indexed for MEDLINE]
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5.	Nature. 2010 Aug 12;466(7308):808-10. Francis Collins: One year at the helm. Wadman M.
	PMID: 20703281 [PubMed - indexed for MEDLINE]
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6.	Nature. 2010 Aug 12;466(7308):806. Mountain mining damages streams. Gilbert N.
	PMID: 20703278 [PubMed - indexed for MEDLINE]
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