What's new for 'JKB_daily1' in PubMed

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Sender's message: Sepsis or genomics or altitude: JKB_daily1

Sent on Tuesday, 2010 Dec 14
Search (sepsis[MeSH Terms] OR septic shock[MeSH Terms] OR altitude[MeSH Terms] OR genomics[MeSH Terms] OR genetics[MeSH Terms] OR retrotransposons[MeSH Terms] OR macrophage[MeSH Terms]) AND ("2009/8/8"[Publication Date] : "3000"[Publication Date]) AND (("Science"[Journal] OR "Nature"[Journal] OR "The New England journal of medicine"[Journal] OR "Lancet"[Journal] OR "Nature genetics"[Journal] OR "Nature medicine"[Journal]) OR (Hume DA[Author] OR Baillie JK[Author] OR Faulkner, Geoffrey J[Author]))
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PubMed Results

Items 1 - 8 of 8

1.	Nat Med. 2010 Nov;16(11):1215-7. Epub 2010 Sep 21. The future of genetic research on neurodegeneration. Van Broeckhoven C. Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium. christine.vanbroeckhoven@molgen.vib-ua.be Abstract Why, with all the progress in the field of neurodegeneration, do we still lack disease-modifying drugs that tackle the primary defect of severe cell loss? How much progress has been made toward this goal? Have we spent our time and resources wisely? And, most important, is there room for improvement? This commentary highlights several problems faced by researchers in studying the genetic etiology of neurodegenerative diseases and seeks to provide direction in overcoming some of these obstacles.
	PMID: 21052076 [PubMed - indexed for MEDLINE]
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2.	Nat Med. 2010 Nov;16(11):1169. Breakup of genetics advisory panel seen as premature. Chi KR.
	PMID: 21052050 [PubMed - indexed for MEDLINE]
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3.	Science. 2010 Nov 5;330(6005):783-8. Changing face of microglia. Graeber MB. Brai n and Mind Research Institute, University of Sydney, Camperdown, NSW 2050, Australia. manuel@graeber.net Abstract Microglia are resident brain cells that sense pathological tissue alterations. They can develop into brain macrophages and perform immunological functions. However, expression of immune proteins by microglia is not synonymous with inflammation, because these molecules can have central nervous system (CNS)-specific roles. Through their involvement in pain mechanisms, microglia also respond to external threats. Experimental studies support the idea that microglia have a role in the maintenance of synaptic integrity. Analogous to electricians, they are capable of removing defunct axon terminals, thereby helping neuronal connections to stay intact. Microglia in healthy CNS tissue do not qualify as macrophages, and their specific functions are beginning to be explored.
	PMID: 21051630 [PubMed - indexed for MEDLINE]
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4.	Lancet. 2010 Oct 30;376(9751):1457. David Weatherall: Lasker Award for pioneer in molecular medicine. Watts G. geoff @scileg.freeserve.co.uk
	PMID: 21036263 [PubMed - indexed for MEDLINE]
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5.	Science. 2010 Nov 5;330(6005):841-5. Epub 2010 Oct 21. Fate mapping analysis reveals that adult microglia derive from primitive macrophages.< /a> Ginhoux F, Greter M, Leboeuf M, Nandi S, See P, Gokhan S, Mehler MF, Conway SJ, Ng LG, Stanley ER, Samokhvalov IM, Merad M. Department of Gene and Cell Medicine and the Immunology Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA. Florent_ginhoux@immunol.a-star.edu.sg Comment in: Nat Rev Neurosci. 2010 Dec;11(12):787. Nat Rev Immunol. 2010 Dec;10(12):808. Abstract Microglia are the resident macrophages of the central nervous system and are associated with the pathogenesis of many neurodegenerative and brain inflammatory diseases; however, the origin of adult microglia remains controversial. We show that postnatal hematopoietic progenitors do not significantly contribute to microglia homeostasis in the adult brain. In contrast to many macrophage populations, we show that microglia develop in mice that lack colony stimulating factor-1 (CSF-1) but are absent in CSF-1 receptor-deficient mice. In vivo lineage tracing studies established that adult microglia derive from primitive myeloid progenitors that arise before embryonic day 8. These results identify microglia as an ontogenically distinct population in the mononuclear phagocyte system and have implications for the use of embryonically derived microglial progenitors for the treatment of various brain disorders.
	PMID: 20966214 [PubMed - indexed for MEDLINE]
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6.	Nature. 2010 Oct 14;467(7317):779-81. Biology without borders. Schindel DE. Consortium for the Barcode of Life, Washington DC, USA. schindeld@si.edu
	PMID: 20944713 [PubMed - indexed for MEDLINE]
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7.	Nature. 2010 Oct 14;467(7317):766-7. Cancer-gene testing ramps up. Callaway E.
	PMID: 20944708 [PubMed - indexed for MEDLINE]
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8.	Nature. 2010 Oct 14;467(7317):S4. A runaway success. Penzias AA.
	PMID: 20944619 [PubMed - indexed for MEDLINE]
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