What's new for 'JKB_daily1' in PubMed

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Sender's message: Sepsis or genomics or altitude: JKB_daily1

Sent on Friday, 2012 May 11
Search: (sepsis[MeSH Terms] OR septic shock[MeSH Terms] OR altitude[MeSH Terms] OR genomics[MeSH Terms] OR genetics[MeSH Terms] OR retrotransposons[MeSH Terms] OR macrophage[MeSH Terms]) AND ("2009/8/8"[Publication Date] : "3000"[Publication Date]) AND (("Science"[Journal] OR "Nature"[Journal] OR "The New England journal of medicine"[Journal] OR "Lancet"[Journal] OR "Nature genetics"[Journal] OR "Nature medicine"[Journal]) OR (Hume DA[Author] OR Baillie JK[Author] OR Faulkner, Geoffrey J[Author]))

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PubMed Results

Items 1 - 4 of 4

1.	Science. 2012 Apr 27;336(6080):433. Science policy. The payoff of federal R&D: iPod, Google, and Human Genome Project. Lane E, Ham B.
	PMID: 22548216 [PubMed - indexed for MEDLINE]
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2.	Science. 2012 Apr 27;336(6080):425-6. Cell Biology. Using cell-to-cell variability--a new era in molecular biology. Pelkmans L. Source Institute of Molecular Life Sciences, University of Zurich, Zürich, Switzerland. lucas.pelkmans@imls.uzh.ch
	PMID: 22539709 [PubMed - indexed for MEDLINE]
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3.	Science. 2012 Apr 27;336(6080):420-1. Immunology. Select inflammasome assembly. Caffrey DR, Fitzgerald KA. Source Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. Comment on Science. 2012 Apr 27;336(6080):481-5.
	PMID: 22539706 [PubMed - indexed for MEDLINE]
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4.	Science. 2012 Apr 27;336(6080):481-5. Epub 2012 Mar 29. GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals. Shenoy AR, Wellington DA, Kumar P, Kassa H, Booth CJ, Cresswell P, MacMicking JD. Source Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06510, USA. Comment in Science. 2012 Apr 27;336(6080):420-1. Abstract Inflammasomes are sensory complexes that alert the immune system to the presence of infection or tissue damage. These complexes assemble NLR (nucleotide binding and oligomerization, leucine-rich repeat) or ALR (absent in melanoma 2-like receptor) proteins to activate caspase-1 cleavage and interleukin (IL)-1β/IL-18 secretion. Here, we identified a non-NLR/ALR human protein that stimulates inflammasome assembly: guanylate binding protein 5 (GBP5). GBP5 promoted selective NLRP3 inflammasome responses to pathogenic bacteria and soluble but not crystalline inflammasome priming agents. Generation of Gbp5(-/-) mice revealed pronounced caspase-1 and IL-1β/IL-18 cleavage defects in vitro and impaired host defense and Nlrp3-dependent inflammatory responses in vivo. Thus, GBP5 serves as a unique rheostat for NLRP3 inflammasome activation and extends our understanding of the inflammasome complex beyond its core machinery.
	PMID: 22461501 [PubMed - indexed for MEDLINE]
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