What's new for 'JKB_daily1' in PubMed

This message contains My NCBI what's new results from the National Center for Biotechnology Information (NCBI) at the U.S. National Library of Medicine (NLM).
Do not reply directly to this message.

Sender's message: Sepsis or genomics or altitude: JKB_daily1

Sent on Thursday, 2012 August 09
Search: (sepsis[MeSH Terms] OR septic shock[MeSH Terms] OR altitude[MeSH Terms] OR genomics[MeSH Terms] OR genetics[MeSH Terms] OR retrotransposons[MeSH Terms] OR macrophage[MeSH Terms]) AND ("2009/8/8"[Publication Date] : "3000"[Publication Date]) AND (("Science"[Journal] OR "Nature"[Journal] OR "The New England journal of medicine"[Journal] OR "Lancet"[Journal] OR "Nature genetics"[Journal] OR "Nature medicine"[Journal]) OR (Hume DA[Author] OR Baillie JK[Author] OR Faulkner, Geoffrey J[Author]))

Click here to view complete results in PubMed (Results may change over time.)
To unsubscribe from these e-mail updates click here.

PubMed Results

Items 1 - 4 of 4

1.	Science. 2012 Jul 27;337(6093):426-7. IBI series winner. Engaging students in molecular biology via case-based learning. Bergland M, Klyczek K, Lin CC, Lundeberg M, Tosado-Acevedo R, Toro A, White D, Wolter B. Source Biology Department, University of Wisconsin-River Falls, River Falls, WI 54022, USA. mark.s.bergland@uwrf.edu Free Article
	PMID: 22837518 [PubMed - indexed for MEDLINE]
	Related citations

2.	Science. 2012 Jul 27;337(6093):424-5. IBI series winner. Aipotu: simulation from nucleotides to populations and back again. White BT. Source Biology Department, University of Massachusetts, Boston, 100 Morrissey Boulevard, Boston, MA 02125, USA. brian.white@umb.edu Free Article
	PMID: 22837517 [PubMed - indexed for MEDLINE]
	Related citations

3.	Science. 2012 Jul 27;337(6093):463-6. Epub 2012 Jun 14. Adenylate cyclases of Trypanosoma brucei inhibit the innate immune response of the host. Salmon D, Vanwalleghem G, Morias Y, Denoeud J, Krumbholz C, Lhommé F, Bachmaier S, Kador M, Gossmann J, Dias FB, De Muylder G, Uzureau P, Magez S, Moser M, De Baetselier P, Van Den Abbeele J, Beschin A, Boshart M, Pays E. Source Laboratory of Molecular Parasitology, Institute for Molecular Biology and Medicine, Université Libre de Bruxelles, 12, rue des Professeurs Jeener et Brachet, B6041 Gosselies, Belgium. salmon@bioqmed.ufrj.br Abstract The parasite Trypanosoma brucei possesses a large family of transmembrane receptor-like adenylate cyclases. Activation of these enzymes requires the dimerization of the catalytic domain and typically occurs under stress. Using a dominant-negative strategy, we found that reducing adenylate cyclase activity by about 50% allowed trypanosome growth but reduced the parasite's ability to control the early innate immune defense of the host. Specifically, activation of trypanosome adenylate cyclase resulting from parasite phagocytosis by liver myeloid cells inhibited the synthesis of the trypanosome-controlling cytokine tumor necrosis factor-α through activation of protein kinase A in these cells. Thus, adenylate cyclase activity of lyzed trypanosomes favors early host colonization by live parasites. The role of adenylate cyclases at the host-parasite interface could explain the expansion and polymorphism of this gene family.
	PMID: 22700656 [PubMed - indexed for MEDLINE]
	Related citations

4.	Nature. 2012 Jun 6;486(7401):17. doi: 10.1038/486017a. Ancestry testing goes for pinpoint accuracy. Callaway E.
	PMID: 22678260 [PubMed - indexed for MEDLINE]
	Related citations