What's new for 'JKB_daily1' in PubMed

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Sender's message: Sepsis or genomics or altitude: JKB_daily1

Sent on Friday, 2012 September 14
Search: (sepsis[MeSH Terms] OR septic shock[MeSH Terms] OR altitude[MeSH Terms] OR genomics[MeSH Terms] OR genetics[MeSH Terms] OR retrotransposons[MeSH Terms] OR macrophage[MeSH Terms]) AND ("2009/8/8"[Publication Date] : "3000"[Publication Date]) AND (("Science"[Journal] OR "Nature"[Journal] OR "The New England journal of medicine"[Journal] OR "Lancet"[Journal] OR "Nature genetics"[Journal] OR "Nature medicine"[Journal]) OR (Hume DA[Author] OR Baillie JK[Author] OR Faulkner, Geoffrey J[Author]))

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PubMed Results

Items 1 - 6 of 6

1.	Science. 2012 Aug 24;337(6097):957-60. Mapping the origins and expansion of the Indo-European language family. Bouckaert R, Lemey P, Dunn M, Greenhill SJ, Alekseyenko AV, Drummond AJ, Gray RD, Suchard MA, Atkinson QD. Source Department of Computer Science, University of Auckland, Auckland 1142, New Zealand. Comment in Linguistics. New method puts elusive Indo-European homeland in Anatolia. [Science. 2012] Linguistics. New method puts elusive Indo-European homeland in Anatolia.Pringle H. Science. 2012 Aug 24; 337(6097):902. Abstract There are two competing hypotheses for the origin of the Indo-European language family. The conventional view places the homeland in the Pontic steppes about 6000 years ago. An alternative hypothesis claims that the languages spread from Anatolia with the expansion of farming 8000 to 9500 years ago. We used Bayesian phylogeographic approaches, together with basic vocabulary data from 103 ancient and contemporary Indo-European languages, to explicitly model the expansion of the family and test these hypotheses. We found decisive support for an Anatolian origin over a steppe origin. Both the inferred timing and root location of the Indo-European language trees fit with an agricultural expansion from Anatolia beginning 8000 to 9500 years ago. These results highlight the critical role that phylogeographic inference can play in resolving debates about human prehistory.
	PMID: 22923579 [PubMed - indexed for MEDLINE]
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2.	Science. 2012 Aug 24;337(6097):967-71. Epub 2012 Jun 28. Landscape of somatic retrotransposition in human cancers. Lee E, Iskow R, Yang L, Gokcumen O, Haseley P, Luquette LJ 3rd, Lohr JG, Harris CC, Ding L, Wilson RK, Wheeler DA, Gibbs RA, Kucherlapati R, Lee C, Kharchenko PV, Park PJ; Cancer Genome Atlas Research Network. Source Center for Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA. Abstract Transposable elements (TEs) are abundant in the human genome, and some are capable of generating new insertions through RNA intermediates. In cancer, the disruption of cellular mechanisms that normally suppress TE activity may facilitate mutagenic retrotranspositions. We performed single-nucleotide resolution analysis of TE insertions in 43 high-coverage whole-genome sequencing data sets from five cancer types. We identified 194 high-confidence somatic TE insertions, as well as thousands of polymorphic TE insertions in matched normal genomes. Somatic insertions were present in epithelial tumors but not in blood or brain cancers. Somatic L1 insertions tend to occur in genes that are commonly mutated in cancer, disrupt the expression of the target genes, and are biased toward regions of cancer-specific DNA hypomethylation, highlighting their potential impact in tumorigenesis.
	PMID: 22745252 [PubMed - indexed for MEDLINE]
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3.	Science. 2012 Apr 13;336(6078):179-82. Integrating genomes. Zerbino DR, Paten B, Haussler D. Source Center for Biomolecular Sciences and Engineering, University of California, Santa Cruz, CA 95064, USA. Abstract As genomic sequencing projects attempt ever more ambitious integration of genetic, molecular, and phenotypic information, a specialization of genomics has emerged, embodied in the subdiscipline of computational genomics. Models inherited from population genetics, phylogenetics, and human disease genetics merge with those from graph theory, statistics, signal processing, and computer science to provide a rich quantitative foundation for genomics that can only be realized with the aid of a computer. Unleashed on a rapidly increasing sample of the planet's 10(30) organisms, these analyses will have an impact on diverse fields of science while providing an extraordinary new window into the story of life.
	PMID: 22499938 [PubMed - indexed for MEDLINE]
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4.	Science. 2012 Apr 13;336(6078):171. Computational biology. Does it compute? Introduction. Vinson V, Purnell BA, Zahn LM, Travis J.
	PMID: 22499935 [PubMed - indexed for MEDLINE]
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5.	Science. 2012 Apr 13;336(6078):161-2. Neuroscience. Revitalizing remyelination--the answer is circulating. Redmond SA, Chan JR. Source Department of Neurology, University of California, San Francisco, CA 94158, USA.
	PMID: 22499927 [PubMed - indexed for MEDLINE]
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6.	Science. 2012 Mar 9;335(6073):1183. Retrospective. Roy J. Britten (1919-2012). Davidson EH. Source California Institute of Technology, Pasadena, CA 91125, USA. davidson@caltech.edu
	PMID: 22403381 [PubMed - indexed for MEDLINE]
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