What's new for 'JKB_daily1' in PubMed

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Sender's message: Sepsis or genomics or altitude: JKB_daily1

Sent on Wednesday, 2013 March 06
Search: (sepsis[MeSH Terms] OR septic shock[MeSH Terms] OR altitude[MeSH Terms] OR genomics[MeSH Terms] OR genetics[MeSH Terms] OR retrotransposons[MeSH Terms] OR macrophage[MeSH Terms]) AND ("2009/8/8"[Publication Date] : "3000"[Publication Date]) AND (("Science"[Journal] OR "Nature"[Journal] OR "The New England journal of medicine"[Journal] OR "Lancet"[Journal] OR "Nature genetics"[Journal] OR "Nature medicine"[Journal]) OR (Hume DA[Author] OR Baillie JK[Author] OR Faulkner, Geoffrey J[Author]))

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PubMed Results

Items 1 - 3 of 3

1.	Science. 2013 Feb 22;339(6122):913-5. doi: 10.1126/science.1228565. Biochemistry. Integrative structural biology. Ward AB, Sali A, Wilson IA. Department of Integrative Structural and Computational Biology, International AIDS Vaccine Initiative Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA. abward@scripps.edu
	PMID: 23430643 [PubMed - indexed for MEDLINE]

2.	Science. 2013 Feb 22;339(6122):912-3. doi: 10.1126/science.1235639. Immunology. Bacterial escape artists set afire. Cemma M, Brumell JH. Cell Biology Program, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada. Comment on Caspase-11 protects against bacteria that escape the vacuole. [Science. 2013] Caspase-11 protects against bacteria that escape the vacuole.Aachoui Y, Leaf IA, Hagar JA, Fontana MF, Campos CG, Zak DE, Tan MH, Cotter PA, Vance RE, Aderem A, et al. Science. 2013 Feb 22; 339(6122):975-8. Epub 2013 Jan 24.
	PMID: 23430642 [PubMed - indexed for MEDLINE]

3.	Science. 2013 Feb 22;339(6122):975-8. doi: 10.1126/science.1230751. Epub 2013 Jan 24. Caspase-11 protects against bacteria that escape the vacuole. Aachoui Y, Leaf IA, Hagar JA, Fontana MF, Campos CG, Zak DE, Tan MH, Cotter PA, Vance RE, Aderem A, Miao EA. Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Comment in Immunology. Bacterial escape artists set afire. [Science. 2013] Immunology. Bacterial escape artists set afire.Cemma M, Brumell JH. Science. 2013 Feb 22; 339(6122):912-3. Abstract Caspases are either apoptotic or inflammatory. Among inflammatory caspases, caspase-1 and -11 trigger pyroptosis, a form of programmed cell death. Whereas both can be detrimental in inflammatory disease, only caspase-1 has an established protective role during infection. Here, we report that caspase-11 is required for innate immunity to cytosolic, but not vacuolar, bacteria. Although Salmonella typhimurium and Legionella pneumophila normally reside in the vacuole, specific mutants (sifA and sdhA, respectively) aberrantly enter the cytosol. These mutants triggered caspase-11, which enhanced clearance of S. typhimurium sifA in vivo. This response did not require NLRP3, NLRC4, or ASC inflammasome pathways. Burkholderia species that naturally invade the cytosol also triggered caspase-11, which protected mice from lethal challenge with B. thailandensis and B. pseudomallei. Thus, caspase-11 is critical for surviving exposure to ubiquitous environmental pathogens.
	PMID: 23348507 [PubMed - indexed for MEDLINE]
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