What's new for 'JKB_daily1' in PubMed
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Sender's message: Sepsis or genomics or altitude: JKB_daily1
Sent on Wednesday, 2013 June 19Search: (sepsis[MeSH Terms] OR septic shock[MeSH Terms] OR altitude[MeSH Terms] OR genomics[MeSH Terms] OR genetics[MeSH Terms] OR retrotransposons[MeSH Terms] OR macrophage[MeSH Terms]) AND ("2009/8/8"[Publication Date] : "3000"[Publication Date]) AND (("Science"[Journal] OR "Nature"[Journal] OR "The New England journal of medicine"[Journal] OR "Lancet"[Journal] OR "Nature genetics"[Journal] OR "Nature medicine"[Journal]) OR (Hume DA[Author] OR Baillie JK[Author] OR Faulkner, Geoffrey J[Author]))
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PubMed Results |
1. | N Engl J Med. 2013 Jun 13;368(24):2331-2. doi: 10.1056/NEJMc1304820#SA5.Daily chlorhexidine bathing and hospital-acquired infection.Krause R, Ribitsch W, Schilcher G.Comment in
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PMID: 23758249 [PubMed - indexed for MEDLINE] | |
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2. | N Engl J Med. 2013 Jun 13;368(24):2331. doi: 10.1056/NEJMc1304820#SA4.Daily chlorhexidine bathing and hospital-acquired infection.Parienti JJ, Cattoir V.Comment in
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PMID: 23758248 [PubMed - indexed for MEDLINE] | |
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3. | N Engl J Med. 2013 Jun 13;368(24):2330-1. doi: 10.1056/NEJMc1304820#SA3.Daily chlorhexidine bathing and hospital-acquired infection.Cooper B, Brun-Buisson C, Bonten M.Comment in
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PMID: 23758247 [PubMed - indexed for MEDLINE] | |
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4. | N Engl J Med. 2013 Jun 13;368(24):2330. doi: 10.1056/NEJMc1304820#SA2.Daily chlorhexidine bathing and hospital-acquired infection.Wolkewitz M, Harbarth S, Beyersmann J.Comment in
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PMID: 23758246 [PubMed - indexed for MEDLINE] | |
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5. | N Engl J Med. 2013 Jun 13;368(24):2330. doi: 10.1056/NEJMc1304820#SA1.Daily chlorhexidine bathing and hospital-acquired infection.Esposito AL.Comment in
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PMID: 23758245 [PubMed - indexed for MEDLINE] | |
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6. | N Engl J Med. 2013 Jun 13;368(24):2332. doi: 10.1056/NEJMc1304820.Daily chlorhexidine bathing and hospital-acquired infection.Climo MW, Wong ES.Comment on
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PMID: 23758244 [PubMed - indexed for MEDLINE] | |
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7. | Lancet. 2013 Jun 1;381(9881):1903. doi: 10.1016/S0140-6736(13)61160-5.Pharmacogenetic testing in the UK clinical setting.Bartlett MJ, Green DW, Shephard EA. |
PMID: 23725729 [PubMed - indexed for MEDLINE] | |
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8. | N Engl J Med. 2013 Jun 13;368(24):2255-65. doi: 10.1056/NEJMoa1207290. Epub 2013 May 29.Targeted versus universal decolonization to prevent ICU infection.Huang SS, Septimus E, Kleinman K, Moody J, Hickok J, Avery TR, Lankiewicz J, Gombosev A, Terpstra L, Hartford F, Hayden MK, Jernigan JA, Weinstein RA, Fraser VJ, Haffenreffer K, Cui E, Kaganov RE, Lolans K, Perlin JB, Platt R; CDC Prevention Epicenters Program; AHRQ DECIDE Network and Healthcare-Associated Infections Program.Collaborators: Huang SS, Septimus E, Kleinman K, Moody J, Hickok J, Avery TR, Lankiewicz J, Gombosev A, Terpstra L, Hartford F, Hayden MK, Jernigan JA, Weinstein RA, Fraser VJ, Haffenreffer K, Cui E, Kaganov RE, Lolans K, Perlin JB, Platt R. University of California Irvine School of Medicine, Orange, CA 92868, USA. sshuang@uci.edu Comment in
AbstractBACKGROUND:Both targeted decolonization and universal decolonization of patients in intensive care units (ICUs) are candidate strategies to prevent health care-associated infections, particularly those caused by methicillin-resistant Staphylococcus aureus (MRSA). METHODS:We conducted a pragmatic, cluster-randomized trial. Hospitals were randomly assigned to one of three strategies, with all adult ICUs in a given hospital assigned to the same strategy. Group 1 implemented MRSA screening and isolation; group 2, targeted decolonization (i.e., screening, isolation, and decolonization of MRSA carriers); and group 3, universal decolonization (i.e., no screening, and decolonization of all patients). Proportional-hazards models were used to assess differences in infection reductions across the study groups, with clustering according to hospital. RESULTS:A total of 43 hospitals (including 74 ICUs and 74,256 patients during the intervention period) underwent randomization. In the intervention period versus the baseline period, modeled hazard ratios for MRSA clinical isolates were 0.92 for screening and isolation (crude rate, 3.2 vs. 3.4 isolates per 1000 days), 0.75 for targeted decolonization (3.2 vs. 4.3 isolates per 1000 days), and 0.63 for universal decolonization (2.1 vs. 3.4 isolates per 1000 days) (P=0.01 for test of all groups being equal). In the intervention versus baseline periods, hazard ratios for bloodstream infection with any pathogen in the three groups were 0.99 (crude rate, 4.1 vs. 4.2 infections per 1000 days), 0.78 (3.7 vs. 4.8 infections per 1000 days), and 0.56 (3.6 vs. 6.1 infections per 1000 days), respectively (P<0.001 for test of all groups being equal). Universal decolonization resulted in a significantly greater reduction in the rate of all bloodstream infections than either targeted decolonization or screening and isolation. One bloodstream infection was prevented per 54 patients who underwent decolonization. The reductions in rates of MRSA bloodstream infection were similar to those of all bloodstream infections, but the difference was not significant. Adverse events, which occurred in 7 patients, were mild and related to chlorhexidine. CONCLUSIONS:In routine ICU practice, universal decolonization was more effective than targeted decolonization or screening and isolation in reducing rates of MRSA clinical isolates and bloodstream infection from any pathogen. (Funded by the Agency for Healthcare Research and the Centers for Disease Control and Prevention; REDUCE MRSA ClinicalTrials.gov number, NCT00980980). |
PMID: 23718152 [PubMed - indexed for MEDLINE] | |
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9. | Science. 2013 May 31;340(6136):1049-50. doi: 10.1126/science.1239119. Epub 2013 May 16.Point-counterpoint. Patient autonomy and incidental findings in clinical genomics.Wolf SM, Annas GJ, Elias S.University of Minnesota, Minneapolis, MN 55455, USA. swolf@umn.edu Comment on
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PMID: 23686341 [PubMed - indexed for MEDLINE] | |
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10. | Science. 2013 May 31;340(6136):1047-8. doi: 10.1126/science.1240156. Epub 2013 May 16.Point-counterpoint. Ethics and genomic incidental findings.McGuire AL, Joffe S, Koenig BA, Biesecker BB, McCullough LB, Blumenthal-Barby JS, Caulfield T, Terry SF, Green RC.Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX 77030, USA. amcguire@bcm.edu Comment in |
PMID: 23686340 [PubMed - indexed for MEDLINE] | |
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11. | Nat Genet. 2013 May;45(5):471. doi: 10.1038/ng.2619.Reply to: "FaST-LMM-Select for addressing confounding from spatial structure and rare variants".Mathieson I, McVean G.Comment on |
PMID: 23619784 [PubMed - indexed for MEDLINE] | |
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12. | Nat Genet. 2013 May;45(5):470-1. doi: 10.1038/ng.2620.FaST-LMM-Select for addressing confounding from spatial structure and rare variants.Listgarten J, Lippert C, Heckerman D.Comment inComment on |
PMID: 23619783 [PubMed - indexed for MEDLINE] | |
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