What's new for 'JKB_daily1' in PubMed

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Sender's message: Sepsis or genomics or altitude: JKB_daily1

Sent on Wednesday, 2013 December 25
Search: (sepsis[MeSH Terms] OR septic shock[MeSH Terms] OR altitude[MeSH Terms] OR genomics[MeSH Terms] OR genetics[MeSH Terms] OR retrotransposons[MeSH Terms] OR macrophage[MeSH Terms]) AND ("2009/8/8"[Publication Date] : "3000"[Publication Date]) AND (("Science"[Journal] OR "Nature"[Journal] OR "The New England journal of medicine"[Journal] OR "Lancet"[Journal] OR "Nature genetics"[Journal] OR "Nature medicine"[Journal]) OR (Hume DA[Author] OR Baillie JK[Author] OR Faulkner, Geoffrey J[Author]))

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PubMed Results

Items 1 - 4 of 4

1.	Science. 2013 Dec 13;342(6164):1335. doi: 10.1126/science.1248808. Retrospective. Michael Neuberger (1953-2013). Sale JE, Patel KJ, Batista FD. Author information: MRC Laboratory of Molecular Biology, Cambridge, UK.
	PMID: 24337288 [PubMed - indexed for MEDLINE]
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2.	Science. 2013 Dec 13;342(6164):1360-4. doi: 10.1126/science.1242335. Epub 2013 Nov 29. The missing mountain water: slower westerlies decrease orographic enhancement in the Pacific Northwest USA. Luce CH, Abatzoglou JT, Holden ZA. Author information: U.S. Forest Service Research and Development, 322 East Front Street, Boise, ID 83702, USA. Abstract Trends in streamflow timing and volume in the Pacific Northwest United States have been attributed to increased temperatures, because trends in precipitation at lower-elevation stations were negligible. We demonstrate that observed streamflow declines are probably associated with declines in mountain precipitation, revealing previously unexplored differential trends. Lower-troposphere winter (November to March) westerlies are strongly correlated with high-elevation precipitation but weakly correlated with low-elevation precipitation. Decreases in lower-tropospheric winter westerlies across the region from 1950 to 2012 are hypothesized to have reduced orographic precipitation enhancement, yielding differential trends in precipitation across elevations and contributing to the decline in annual streamflow. Climate projections show weakened lower-troposphere zonal flow across the region under enhanced greenhouse forcing, highlighting an additional stressor that is relevant for climate change impacts on hydrology.
	PMID: 24292627 [PubMed - indexed for MEDLINE]
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3.	N Engl J Med. 2013 Dec 19;369(25):2369-71. doi: 10.1056/NEJMp1314561. Epub 2013 Nov 19. First FDA authorization for next-generation sequencer. Collins FS, Hamburg MA. Author information: From the Office of the Director, National Institutes of Health, Bethesda, MD (F.S.C.); and the Office of the Commissioner, Food and Drug Administration, Department of Health and Human Services, Silver Spring, MD (M.A.H.). Free Article
	PMID: 24251383 [PubMed - indexed for MEDLINE]
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4.	Science. 2013 Dec 13;342(6164):1379-82. doi: 10.1126/science.1242993. Epub 2013 Nov 14. EMRE is an essential component of the mitochondrial calcium uniporter complex. Sancak Y, Markhard AL, Kitami T, Kovács-Bogdán E, Kamer KJ, Udeshi ND, Carr SA, Chaudhuri D, Clapham DE, Li AA, Calvo SE, Goldberger O, Mootha VK. Author information: Department of Molecular Biology, Massachusetts General Hospital, Department of Systems Biology, Harvard Medical School, Boston, MA, USA. Abstract The mitochondrial uniporter is a highly selective calcium channel in the organelle's inner membrane. Its molecular components include the EF-hand-containing calcium-binding proteins mitochondrial calcium uptake 1 (MICU1) and MICU2 and the pore-forming subunit mitochondrial calcium uniporter (MCU). We sought to achieve a full molecular characterization of the uniporter holocomplex (uniplex). Quantitative mass spectrometry of affinity-purified uniplex recovered MICU1 and MICU2, MCU and its paralog MCUb, and essential MCU regulator (EMRE), a previously uncharacterized protein. EMRE is a 10-kilodalton, metazoan-specific protein with a single transmembrane domain. In its absence, uniporter channel activity was lost despite intact MCU expression and oligomerization. EMRE was required for the interaction of MCU with MICU1 and MICU2. Hence, EMRE is essential for in vivo uniporter current and additionally bridges the calcium-sensing role of MICU1 and MICU2 with the calcium-conducting role of MCU.
	PMID: 24231807 [PubMed - indexed for MEDLINE]
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