What's new for 'JKB_daily1' in PubMed

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Sender's message: Sepsis or genomics or altitude: JKB_daily1

Sent on Wednesday, 2014 October 22
Search: (sepsis[MeSH Terms] OR septic shock[MeSH Terms] OR altitude[MeSH Terms] OR genomics[MeSH Terms] OR genetics[MeSH Terms] OR retrotransposons[MeSH Terms] OR macrophage[MeSH Terms]) AND ("2009/8/8"[Publication Date] : "3000"[Publication Date]) AND (("Science"[Journal] OR "Nature"[Journal] OR "The New England journal of medicine"[Journal] OR "Lancet"[Journal] OR "Nature genetics"[Journal] OR "Nature medicine"[Journal]) OR (Hume DA[Author] OR Baillie JK[Author] OR Faulkner, Geoffrey J[Author]))

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PubMed Results

Items 1 - 3 of 3

1.	Science. 2014 Oct 3;346(6205):1255784. doi: 10.1126/science.1255784. Epub 2014 Oct 2. Proteomics. Tracking cancer drugs in living cells by thermal profiling of the proteome. Savitski MM1, Reinhard FB2, Franken H2, Werner T2, Savitski MF2, Eberhard D2, Martinez Molina D3, Jafari R3, Dovega RB3, Klaeger S4, Kuster B4, Nordlund P5, Bantscheff M1, Drewes G1. Author information: 1Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline, Meyerhofstrasse 1, Heidelberg, Germany. mikhail.m.savitski@gsk.com marcus.x.bantscheff@gsk.com gerard.c.drewes@gsk.com. 2Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline, Meyerhofstrasse 1, Heidelberg, Germany. 3Division of Biophysics, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. 4Department of Proteomics and Bioanalytics, Technische Universität München, Emil Erlenmeyer Forum 5, Freising, Germany. German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany. 5Division of Biophysics, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. Centre for Biomedical Structural Biology, Nanyang Technological University, Singapore. Abstract The thermal stability of proteins can be used to assess ligand binding in living cells. We have generalized this concept by determining the thermal profiles of more than 7000 proteins in human cells by means of mass spectrometry. Monitoring the effects of small-molecule ligands on the profiles delineated more than 50 targets for the kinase inhibitor staurosporine. We identified the heme biosynthesis enzyme ferrochelatase as a target of kinase inhibitors and suggest that its inhibition causes the phototoxicity observed with vemurafenib and alectinib. Thermal shifts were also observed for downstream effectors of drug treatment. In live cells, dasatinib induced shifts in BCR-ABL pathway proteins, including CRK/CRKL. Thermal proteome profiling provides an unbiased measure of drug-target engagement and facilitates identification of markers for drug efficacy and toxicity. Copyright © 2014, American Association for the Advancement of Science.
	PMID: 25278616 [PubMed - indexed for MEDLINE]
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2.	Science. 2014 Oct 3;346(6205):40-1. doi: 10.1126/science.1259925. Epub 2014 Oct 2. Immunology. A neighborhood watch upholds local immune protection. Carbone FR1, Gebhardt T2. Author information: 1Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC 3010, Australia. f.carbone@microbiology.unimelb.edu.au. 2Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC 3010, Australia. Comment on T cell memory. Skin-resident memory CD8⁺ T cells trigger a state of tissue-wide pathogen alert. [Science. 2014] T cell memory. Skin-resident memory CD8⁺ T cells trigger a state of tissue-wide pathogen alert.Ariotti S, Hogenbirk MA, Dijkgraaf FE, Visser LL, Hoekstra ME, Song JY, Jacobs H, Haanen JB, Schumacher TN. Science. 2014 Oct 3; 346(6205):101-5. Epub 2014 Aug 28. T cell memory. A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells. [Science. 2014] T cell memory. A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells.Iijima N, Iwasaki A. Science. 2014 Oct 3; 346(6205):93-8. Epub 2014 Aug 28. T cell memory. Resident memory CD8 T cells trigger protective innate and adaptive immune responses. [Science. 2014] T cell memory. Resident memory CD8 T cells trigger protective innate and adaptive immune responses.Schenkel JM, Fraser KA, Beura LK, Pauken KE, Vezys V, Masopust D. Science. 2014 Oct 3; 346(6205):98-101. Epub 2014 Aug 28.
	PMID: 25278601 [PubMed - indexed for MEDLINE]
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3.	Science. 2014 Oct 3;346(6205):93-8. doi: 10.1126/science.1257530. Epub 2014 Aug 28. T cell memory. A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells. Iijima N1, Iwasaki A2. Author information: 1Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. 2Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. akiko.iwasaki@yale.edu. Comment in Immunology. A neighborhood watch upholds local immune protection. [Science. 2014] Immunology. A neighborhood watch upholds local immune protection.Carbone FR, Gebhardt T. Science. 2014 Oct 3; 346(6205):40-1. Epub 2014 Oct 2. Abstract CD8 tissue-resident memory T (T(RM)) cells provide efficient local control of viral infection, but the role of CD4 T(RM) is less clear. Here, by using parabiotic mice, we show that a preexisting pool of CD4 T(RM) cells in the genital mucosa was required for full protection from a lethal herpes simplex virus 2 (HSV-2) infection. Chemokines secreted by a local network of macrophages maintained vaginal CD4 T(RM) in memory lymphocyte clusters (MLCs), independently of circulating memory T cells. CD4 T(RM) cells within the MLCs were enriched in clones that expanded in response to HSV-2. Our results highlight the need for vaccine strategies that enable establishment of T(RM) cells for protection from a sexually transmitted virus and provide insights as to how such a pool might be established. Copyright © 2014, American Association for the Advancement of Science.
	PMID: 25170048 [PubMed - indexed for MEDLINE]
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