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Sender's message: Sepsis or genomics or altitude: JKB_daily1

Sent on Tuesday, 2015 February 03
Search: (sepsis[MeSH Terms] OR septic shock[MeSH Terms] OR altitude[MeSH Terms] OR genomics[MeSH Terms] OR genetics[MeSH Terms] OR retrotransposons[MeSH Terms] OR macrophage[MeSH Terms]) AND ("2009/8/8"[Publication Date] : "3000"[Publication Date]) AND (("Science"[Journal] OR "Nature"[Journal] OR "The New England journal of medicine"[Journal] OR "Lancet"[Journal] OR "Nature genetics"[Journal] OR "Nature medicine"[Journal]) OR (Hume DA[Author] OR Baillie JK[Author] OR Faulkner, Geoffrey J[Author]))

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PubMed Results

Items 1 - 4 of 4

1.	Nature. 2015 Jan 15;517(7534):252-3. doi: 10.1038/517252a. 'I can haz genomes': cats claw their way into genetics. Callaway E.
	PMID: 25592511 [PubMed - indexed for MEDLINE]
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2.	Nature. 2015 Jan 15;517(7534):244. doi: 10.1038/517244b. Out of the bag. [No authors listed]
	PMID: 25592497 [PubMed - indexed for MEDLINE]
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3.	Nature. 2015 Jan 15;517(7534):276-7. doi: 10.1038/nature14077. Epub 2014 Dec 3. Genomics: African dawn. Ramesar R1. Comment on The African Genome Variation Project shapes medical genetics in Africa. [Nature. 2015] The African Genome Variation Project shapes medical genetics in Africa.Gurdasani D, Carstensen T, Tekola-Ayele F, Pagani L, Tachmazidou I, Hatzikotoulas K, Karthikeyan S, Iles L, Pollard MO, Choudhury A, et al. Nature. 2015 Jan 15; 517(7534):327-32. Epub 2014 Dec 3.
	PMID: 25470066 [PubMed - indexed for MEDLINE]
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4.	Nature. 2015 Jan 15;517(7534):327-32. doi: 10.1038/nature13997. Epub 2014 Dec 3. The African Genome Variation Project shapes medical genetics in Africa. Gurdasani D1, Carstensen T1, Tekola-Ayele F2, Pagani L3, Tachmazidou I4, Hatzikotoulas K4, Karthikeyan S1, Iles L5, Pollard MO4, Choudhury A6, Ritchie GR7, Xue Y4, Asimit J4, Nsubuga RN8, Young EH1, Pomilla C1, Kivinen K4, Rockett K9, Kamali A8, Doumatey AP2, Asiki G8, Seeley J8, Sisay-Joof F10, Jallow M10, Tollman S11, Mekonnen E12, Ekong R13, Oljira T14, Bradman N15, Bojang K10, Ramsay M16, Adeyemo A2, Bekele E17, Motala A18, Norris SA19, Pirie F18, Kaleebu P8, Kwiatkowski D20, Tyler-Smith C4, Rotimi C2, Zeggini E4, Sandhu MS1. Comment in Genomics: African dawn. [Nature. 2015] Genomics: African dawn.Ramesar R. Nature. 2015 Jan 15; 517(7534):276-7. Epub 2014 Dec 3. Abstract Given the importance of Africa to studies of human origins and disease susceptibility, detailed characterization of African genetic diversity is needed. The African Genome Variation Project provides a resource with which to design, implement and interpret genomic studies in sub-Saharan Africa and worldwide. The African Genome Variation Project represents dense genotypes from 1,481 individuals and whole-genome sequences from 320 individuals across sub-Saharan Africa. Using this resource, we find novel evidence of complex, regionally distinct hunter-gatherer and Eurasian admixture across sub-Saharan Africa. We identify new loci under selection, including loci related to malaria susceptibility and hypertension. We show that modern imputation panels (sets of reference genotypes from which unobserved or missing genotypes in study sets can be inferred) can identify association signals at highly differentiated loci across populations in sub-Saharan Africa. Using whole-genome sequencing, we demonstrate further improvements in imputation accuracy, strengthening the case for large-scale sequencing efforts of diverse African haplotypes. Finally, we present an efficient genotype array design capturing common genetic variation in Africa. PMCID: PMC4297536 [Available on 2015/7/15]
	PMID: 25470054 [PubMed - indexed for MEDLINE]
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