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Sender's message: Sepsis or genomics or altitude: JKB_daily1

Sent on Thursday, 2010 Feb 18
Search (sepsis[MeSH Terms] OR septic shock[MeSH Terms] OR altitude[MeSH Terms] OR genomics[MeSH Terms] OR genetics[MeSH Terms] OR retrotransposons[MeSH Terms] OR macrophage[MeSH Terms]) AND ("2009/8/8"[Publication Date] : "3000"[Publication Date]) AND (("Science"[Journal] OR "Nature"[Journal] OR "The New England journal of medicine"[Journal] OR "Lancet"[Journal] OR "Nature genetics"[Journal] OR "Nature medicine"[Journal]) OR (Hume DA[Author] OR Baillie JK[Author] OR Faulkner, Geoffrey J[Author]))
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PubMed Results

Items 1 -5 of 5

1.	Nature. 2010 Jan 28;463(7280):425. Mind the gap: social sciences can reveal community needs. Morris C. Comment on: Nature. 2009 Dec 17;462(7275):825-6.
	PMID: 20110970 [PubMed - indexed for MEDLINE]
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	Publication Types: Comment Letter MeSH Terms: Molecular Biology*/methods Molecular Biology*/trends Residence Characteristics Social Sciences*/trends Software Design

2.	Science. 2010 Jan 29;327(5965):538-9. Winner of Science Prize fo r Online Resources in Education. Making genetics easy to understand. Stark LA, Pompei K. Genetic Science Learning Center, University of Utah, Salt Lake City, UT 84112, USA. louisa.stark@utah.edu
	PMID: 20110495 [PubMed - indexed for MEDLINE]
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	Publication Types: Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. MeSH Terms: Awards and Prizes Computer-Assisted Instruction* Curriculum Education Genetics/education* Genomics/education* Internet* Online Systems* Teaching Teaching Materials Grant Support: Howard Hughes Medical Institute/United States

3.	Science. 2010 Jan 29;327(5965):504. Science education web sites. Alberts B.
	PMID: 20110470 [PubMed - indexed for MEDLINE]
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	Publication Types: Editorial MeSH Terms: Awards and Prizes* Computer-Assisted Instruction* Genetics/education* Internet* Online Systems* Science/education* Teaching

4.	Lancet. 2010 Jan 16;375(9710):224-30. Epub 2009 Dec 10. Accurate and rapid identification of bacterial species from positive blood cultures with a DNA-based microarray platform: an observational study.Tissari P, Zumla A, Tarkka E, Mero S, Savolainen L, Vaara M, Aittakorpi A, Laakso S, Lindfors M, Piiparinen H, Mäki M, Carder C, Huggett J, Gant V. Division of Clinical Microbiology, Helsinki University Hospital Laboratory, Helsinki, Finland. Comment in: Lancet. 2010 Jan 16;375(9710):178-9. BACKGROUND: New DNA-based microarray platforms enable rapid detection and species identification of many pathogens, including bacteria. We assessed the sensitivity, specificity, and turnaround time of a new molecular sepsis assay. METHODS: 2107 positive blood-culture samples of 3318 blood samples from patients with clinically suspected sepsis were investigated for bacterial species by both conventional culture and Prove-it sepsis assay (Mobidiag, Helsinki, Finland) in two centres (UK and Finland). The assay is a novel PCR and microarray method that is based on amplification and detection of gyrB, parE, and mecA genes of 50 bacterial species. Operators of the test assay were not aware of culture results. We calculated sensitivity, specificity, and turnaround time according to Clinical and Laboratory Standards Institute recommendations. FINDINGS: 1807 of 2107 (86%) positive blood-culture samples included a pathogen covered by the assay. The assay had a clinical sensitivity of 94.7% (95% CI 93.6-95.7) and a specificity of 98.8% (98.1-99.2), and 100% for both measures for meticillin-resistant Staphylococcus aureus bacteraemia. The assay was a mean 18 h faster than was the conventional culture-based method, which takes an additional 1-2 working days. 34 of 3284 (1.0%) samples were excluded because of technical and operator errors. INTERPRETATION: Definitive identification of bacterial species with this microarray platform was highly sensitive, specific, and faster than was the gold-standard culture-based method. This assay could enable fast and earlier evidence-based management for clinical sepsis. Copyright 2010 Elsevier Ltd. All rights reserved.
	PMID: 20004964 [PubMed - indexed for MEDLINE]
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	MeSH Terms: Bacteremia/microbiology* Bacteria/isolation & purification* Bacterial Proteins/analysis Bacteriological Techniques DNA Gyrase/analysis DNA Topoisomerase IV/analysis DNA, Bacterial/analysis* Drug Resistance, Bacterial/genetics Genes, Bacterial Humans Nucleic Acid Amplification Techniques Oligonucleotide Array Sequence Analysis* Polymerase Chain Reaction* Sensitivity and Specificity Substances: Bacterial Proteins DNA, Bacterial mecA protein, Staphylococcus aureus DNA Gyrase DNA Topoisomerase IV

5.	Lancet. 2010 Jan 16;375(9710):178-9. Epub 2009 Dec 10. Molecular methods for pathogen detection in blood. Lin S, Yang S. Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. Comment on: Lancet. 2010 Jan 16;375(9710):224-30.
	PMID: 20004963 [PubMed - indexed for MEDLINE]
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	Publication Types: Comment MeSH Terms: Bacteremia/microbiology* Bacteria/isolation & purification* Bacteriological Techniques DNA, Bacterial/analysis* Humans Nucleic Acid Amplification Techniques Oligonucleotide Array Sequence Analysis Polymerase Chain Reaction Sensitivity and Specificity Substances: DNA, Bacterial