What's new for 'JKB_daily1' in PubMed

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Sender's message: Sepsis or genomics or altitude: JKB_daily1

Sent on Saturday, 2010 Mar 13
Search (sepsis[MeSH Terms] OR septic shock[MeSH Terms] OR altitude[MeSH Terms] OR genomics[MeSH Terms] OR genetics[MeSH Terms] OR retrotransposons[MeSH Terms] OR macrophage[MeSH Terms]) AND ("2009/8/8"[Publication Date] : "3000"[Publication Date]) AND (("Science"[Journal] OR "Nature"[Journal] OR "The New England journal of medicine"[Journal] OR "Lancet"[Journal] OR "Nature genetics"[Journal] OR "Nature medicine"[Journal]) OR (Hume DA[Author] OR Baillie JK[Author] OR Faulkner, Geoffrey J[Author]))
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PubMed Results

Items 1 - 3 of 3

1.	Nature. 2010 Feb 4;463(7281):596-7. Project set to map marks on genome. Abbott A.
	PMID: 20162836 [PubMed - indexed for MEDLINE]
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	Publication Types: News MeSH Terms: Case-Control Studies Epigenesis, Genetic/genetics* Genome, Human/genetics* Genomics/economics Genomics/organization & administration* Genomics/standards Genomics/trends* Humans International Cooperation Reference Values

2.	Nature. 2010 Feb 4;463(7281):632-6. Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte. Russo I, Babbitt S, Muralidharan V, Butler T, Oksman A, Goldberg DE. Howard Hughes Medical Institute, Washington University School of Medicine, Department of Molecular Microbiology, St Louis, Missouri 63110, USA. During their intraerythrocytic development, malaria parasites export hundreds of proteins to remodel their host cell. Nutrient acquisition, cytoadherence and antigenic variation are among the key virulence functions effected by this erythrocyte takeover. Proteins destined for export are synthesized in the endoplasmic reticulum (ER) and cleaved at a conserved (PEXEL) motif, which allows translocation into the host cell via an ATP-driven translocon called the PTEX complex. We report that plasmepsin V, an ER aspartic protease with distant homology to the mammalian processing enzyme BACE, recognizes the PEXEL motif and cleaves it at the correct site. This enzyme is essential for parasite viability and ER residence is essential for its function. We propose that plasmepsin V is the PEXEL protease and is an attractive enzyme for antimalarial drug development. PMCID: PMC2826791 [Available on 2010/8/4]
	PMID: 20130644 [PubMed - indexed for MEDLINE]
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	Publication Types: Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't MeSH Terms: Amino Acid Motifs Animals Antimalarials/pharmacology Aspartic Acid Endopeptidases/antagonists & inhibitors Aspartic Acid Endopeptidases/chemistry Aspartic Acid Endopeptidases/genetics Aspartic Acid Endopeptidases/metabolism* Biocatalysis/drug effects Endoplasmic Reticulum/enzymology Endoplasmic Reticulum/metabolism Erythrocytes/cytology Erythrocytes/metabolism* Erythrocytes/parasitology Genes, Dominant Genes, Essential HIV Protease Inhibitors/pharmacology Humans Malaria, Falciparum/blood* Malaria, Falciparum/metabolism Malaria, Falciparum/parasitology* Malaria, Falciparum/pathology Multiprotein Complexes/metabolism Pepstatins/pharmacology Phenotype Plasmids/genetics Plasmodium falciparum/enzymology Plasmodium falciparum/genetics Plasmodium falciparum/metabolism* Plasmodium falciparum/pathogenicity Protein Binding Protein Sorting Signals Protein Structure, Tertiary Protein Transport Proteomics Protozoan Proteins/chemistry Protozoan Proteins/metabolism* Substrate Specificity Substances: Antimalarials HIV Protease Inhibitors Multiprotein Complexes Pepstatins Protein Sorting Signals Protozoan Proteins pepstatin Aspartic Acid Endopeptidases plasmepsin Grant Support: AI-047798/AI/NIAID NIH HHS/United States Howard Hughes Medical Institute/United States

3.	Nature. 2010 Feb 4;463(7281):587. Time for the epigenome. [No authors listed]
	PMID: 20130607 [PubMed - in dexed for MEDLINE]
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	Publication Types: Editorial MeSH Terms: Epigenesis, Genetic/genetics* Genome, Human/genetics* Genomics/trends* Humans Internationality Reference Values Time Factors