What's new for 'JKB_daily1' in PubMed

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Sender's message: Sepsis or genomics or altitude: JKB_daily1

Sent on Wednesday, 2010 Jul 14
Search (sepsis[MeSH Terms] OR septic shock[MeSH Terms] OR altitude[MeSH Terms] OR genomics[MeSH Terms] OR genetics[MeSH Terms] OR retrotransposons[MeSH Terms] OR macrophage[MeSH Terms]) AND ("2009/8/8"[Publication Date] : "3000"[Publication Date]) AND (("Science"[Journal] OR "Nature"[Journal] OR "The New England journal of medicine"[Journal] OR "Lancet"[Journal] OR "Nature genetics"[Journal] OR "Nature medicine"[Journal]) OR (Hume DA[Author] OR Baillie JK[Author] OR Faulkner, Geoffrey J[Author]))
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PubMed Results

Items 1 - 6 of 6

1.	Science. 2010 Jul 2;329(5987):75-8. Sequencing of 50 human exomes reveals adaptation to high altitude. Yi X, Liang Y, Huerta-Sanchez E, Jin X, Cuo ZX, Pool JE, Xu X, Jiang H, Vinckenbosch N, Korneliussen TS, Zheng H, Liu T, He W, Li K, Luo R, Nie X, Wu H, Zhao M, Cao H, Zou J, Shan Y, Li S, Yang Q, Asan, Ni P, Tian G, Xu J, Liu X, Jiang T, Wu R, Zhou G, Tang M, Qin J, Wang T, Feng S, Li G, Huasang, Luosang J, Wang W, Chen F, Wang Y, Zheng X, Li Z, Bianba Z, Yang G, Wang X, Tang S, Gao G, Chen Y, Luo Z, Gusang L, Cao Z, Zhang Q, Ouyang W, Ren X, Liang H, Zheng H, Huang Y, Li J, Bolund L, Kristiansen K, Li Y, Zhang Y, Zhang X, Li R, Li S, Yang H, Nielsen R, Wang J, Wang J. BGI-Shenzhen, Shenzhen 518083, China. Comment in: Science. 2010 Jul 2;329(5987):40-1. Abstract Residents of the Tibetan Plateau show heritable adaptations to extreme altitude. We sequenced 50 exomes of ethnic Tibetans, encompassing coding sequences of 92% of human genes, with an average coverage of 18x per individual. Genes showing population-specific allele frequency changes, which represent strong candidates for altitude adaptation, were identified. The strongest signal of natural selection came from endothelial Per-Arnt-Sim (PAS) domain protein 1 (EPAS1), a transcription factor involved in response to hypoxia. One single-nucleotide polymorphism (SNP) at EPAS1 shows a 78% frequency difference between Tibetan and Han samples, representing the fastest allele frequency change observed at any human gene to date. This SNP's association with erythrocyte abundance supports the role of EPAS1 in adaptation to hypoxia. Thus, a population genomic survey has revealed a functionally important locus in genetic adaptation to high altitude.
	PMID: 20595611 [PubMed - indexed for MEDLINE]
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2.	Science. 2010 Jul 2;329(5987):40-1. Evolution. Genes for high altitudes. Storz JF. School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA. jstorz2@unl.edu Comment on: Science. 2010 Jul 2;329(5987):75-8. Science. 2010 Jul 2;329(5987):72-5.
	PMID: 20595602 [PubMed - indexed for MEDLINE]
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3.	Science. 2010 Jul 2;329(5987):38-9. Genetic technologies. Synthetic "life," ethics, national security, and public discourse. Cho MK, Relman DA. Stanford University, Stanford, CA 94305, USA. micho@stanford.edu Comment on: Science. 2010 Jul 2;329(5987):52-6.
	PMID: 20595601 [PubMed - indexed for MEDLINE]
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4.	Science. 2010 Jul 2;329(5987):32-3. Variability of our somatic (epi)genomes. Sgaramella V.
	PMID: 20595596 [PubMed - indexed for MEDLINE]
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5.	Science. 2010 Jul 2;329(5987):24-7. Epigenetics. The seductive allure of behavioral epigenetics. Miller G.
	PMID: 20595592 [PubMed - indexed for MEDLINE]
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6.	Science. 2010 Jul 2;329(5987):72-5. Epub 2010 May 13. Genetic evidence for high-altitude adaptation in Tibet. Simonson TS, Yang Y, Huff CD, Yun H, Qin G, Witherspoon DJ, Bai Z, Lorenzo FR, Xing J, Jorde LB, Prchal JT, Ge R. Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA. Comment in: Science. 2010 Jul 2;329(5987):40-1. Abstract Tibetans have lived at very high altitudes for thousands of years, and they have a distinctive suite of physiological traits that enable them to tolerate environmental hypoxia. These phenotypes are clearly the result of adaptation to this environment, but their genetic basis remains unknown. We report genome-wide scans that reveal positive selection in several regions that contain genes whose products are likely involved in high-altitude adaptation. Positively selected haplotypes of EGLN1 and PPARA were significantly associated with the decreased hemoglobin phenotype that is unique to this highland population. Identification of these genes provides support for previously hypothesized mechanisms of high-altitude adaptation and illuminates the complexity of hypoxia-response pathways in humans.
	PMID: 20466884 [PubMed - indexed for MEDLINE]
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