What's new for 'JKB_daily1' in PubMed

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Sender's message: Sepsis or genomics or altitude: JKB_daily1

Sent on Wednesday, 2010 Aug 11
Search (sepsis[MeSH Terms] OR septic shock[MeSH Terms] OR altitude[MeSH Terms] OR genomics[MeSH Terms] OR genetics[MeSH Terms] OR retrotransposons[MeSH Terms] OR macrophage[MeSH Terms]) AND ("2009/8/8"[Publication Date] : "3000"[Publication Date]) AND (("Science"[Journal] OR "Nature"[Journal] OR "The New England journal of medicine"[Journal] OR "Lancet"[Journal] OR "Nature genetics"[Journal] OR "Nature medicine"[Journal]) OR (Hume DA[Author] OR Baillie JK[Author] OR Faulkner, Geoffrey J[Author]))
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PubMed Results

Items 1 - 3 of 3

1.	Science. 2010 Jul 23;329(5990):397-8. Medicine. Wnt fans the flames in obesity. Oh da Y, Olefsky JM. Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, CA 92093, USA. Comment on: Science. 2010 Jul 23;329(5990):454-7.
	PMID: 20651140 [PubMed - indexed for MEDLINE]
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2.	Science. 2010 Jul 23;329(5990):393-4. Information access. Prepublication data release, latency, and genome commons. Contreras JL. School of Law, Washington University in St. Louis, St. Louis, MO 63130, USA. jlcontreras@wulaw.wustl.edu
	PMID: 20651137 [PubMed - indexed for MEDLINE]
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3.	Science. 2010 Jul 23;329(5990):454-7. Epub 2010 Jun 17. Sfrp5 is an anti-inflammatory adipokine that modulates m etabolic dysfunction in obesity. Ouchi N, Higuchi A, Ohashi K, Oshima Y, Gokce N, Shibata R, Akasaki Y, Shimono A, Walsh K. Molecular Cardiology and Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, MA 02118, USA. nouchi@bu.edu Comment in: Science. 2010 Jul 23;329(5990):397-8. Nat Rev Drug Discov. 2010 Aug;9(8):594. Nat Rev Immunol. 2010 Aug;10(8):540. Abstract Adipose tissue secretes proteins referred to as adipokines, many of which promote inflammation and disrupt glucose homeostasis. Here we show that secreted frizzled-related protein 5 (Sfrp5), a protein previously linked to the Wnt signaling pathway, is an anti-inflammatory adipokine whose expression is perturbed in models of obesity and type 2 diabetes. Sfrp5-deficient mice fed a high-calorie diet developed severe glucose intolerance and hepatic steatosis, and their adipose tissue showed an accumulation of activated macrophages that was associated with activation of the c-Jun N-terminal kinase signaling pathway. Adenovirus-mediated delivery of Sfrp5 to mouse models of obesity ameliorated glucose intolerance and hepatic steatosis. Thus, in the setting of obesity, Sfrp5 secretion by adipocytes exerts salutary effects on metabolic dysfunction by controlling inflammatory cells within adipose tissue.
	PMID: 20558665 [PubMed - indexed for MEDLINE]
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