What's new for 'JKB_daily1' in PubMed

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Sender's message: Sepsis or genomics or altitude: JKB_daily1

Sent on Tuesday, 2011 Jan 25
Search (sepsis[MeSH Terms] OR septic shock[MeSH Terms] OR altitude[MeSH Terms] OR genomics[MeSH Terms] OR genetics[MeSH Terms] OR retrotransposons[MeSH Terms] OR macrophage[MeSH Terms]) AND ("2009/8/8"[Publication Date] : "3000"[Publication Date]) AND (("Science"[Journal] OR "Nature"[Journal] OR "The New England journal of medicine"[Journal] OR "Lancet"[Journal] OR "Nature genetics"[Journal] OR "Nature medicine"[Journal]) OR (Hume DA[Author] OR Baillie JK[Author] OR Faulkner, Geoffrey J[Author]))
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PubMed Results

Items 1 - 4 of 4

1.	Science. 2011 Jan 7;331(6013):17. Chronic fatigue syndrome. Studies point to possible contamination in XMRV findings. Kaiser J.
	PMID: 21212329 [PubMed - indexed for MEDLINE]
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2.	Nat Med. 2010 Dec;16(12):1380-1. Microglial pilgrimage to the brain. [No authors listed]
	PMID: 21135848 [PubMed - indexed for MEDLINE]
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3.	Nat Med. 2010 Dec;16(12):1349. Duke's Discovery Genomics center rides pharmacogenomics wave. Wapner J .
	PMID: 21135823 [PubMed - indexed for MEDLINE]
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4.	Nat Med. 2010 Dec;16(12):1407-13. Epub 2010 Nov 28. T helper type 1 memory cells disseminate postoperative ileus over the entire intestinal tract. Engel DR, Koscielny A, Wehner S, Maurer J, Schiwon M, Franken L, Schumak B, Limmer A, Sparwasser T, Hirner A, Knolle PA, Kalff JC, Kurts C. Institutes for Molecular Medicine and Experimental Immunology, University Clinic of Bonn, Bonn, Germany. Comment in: Nat Med. 2010 Dec;16(12):1378-9. Abstract Localized abdominal surgery can lead to disruption of motility in the entire gastrointestinal tract (postoperative ileus). Intestinal macrophages produce mediators that paralyze myocytes, but it is unclear how the macrophages are activated, especially those in unmanipulated intestinal areas. Here we show that intestinal surgery activates intestinal CD103(+)CD11b(+) dendritic cells (DCs) to produce interleukin-12 (IL-12). This promotes interferon-γ (IFN-γ) secretion by CCR9(+) memory T helper type 1 (T(H)1) cells which activates the macrophages. IL-12 also caused some T(H)1 cells to migrate from surgically manipulated sites through the bloodstream to unmanipulated intestinal areas where they induced ileus. Preventing T cell migration with the drug FTY720 or inhibition of IL-12, T-bet (T(H)1-specific T box transcription factor) or IFN-γ prevented postoperative ileus. CCR9(+) T(H)1 memory cells were detected in the venous blood of subjects 1 h after abdominal surgery. These findings indicate that postoperative ileus is a T(H)1 immune-mediated disease and identify potential targets for disease monitoring and therapy.
	PMID: 21113155 [PubMed - indexed for MEDLINE]
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