What's new for 'JKB_daily1' in PubMed

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Sender's message: Sepsis or genomics or altitude: JKB_daily1

Sent on Tuesday, 2011 Mar 01
Search (sepsis[MeSH Terms] OR septic shock[MeSH Terms] OR altitude[MeSH Terms] OR genomics[MeSH Terms] OR genetics[MeSH Terms] OR retrotransposons[MeSH Terms] OR macrophage[MeSH Terms]) AND ("2009/8/8"[Publication Date] : "3000"[Publication Date]) AND (("Science"[Journal] OR "Nature"[Journal] OR "The New England journal of medicine"[Journal] OR "Lancet"[Journal] OR "Nature genetics"[Journal] OR "Nature medicine"[Journal]) OR (Hume DA[Author] OR Baillie JK[Author] OR Faulkner, Geoffrey J[Author]))
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PubMed Results

Items 1 - 9 of 9

1.	Nature. 2011 Feb 10;470(7333):289-94. Genomics: Genomes in three dimensions. Baker M. Nature and Nature Methods.
	PMID: 21307943 [PubMed - indexed for MEDLINE]
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2.	Nature. 2011 Feb 10;470(7333):284-8. lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3' UTRs via Alu elements. Gong C, Maquat LE. Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA. Abstract Staufen 1 (STAU1)-mediated messenger RNA decay (SMD) involves the degradation of translationally active mRNAs whose 3'-untranslated regions (3' UTRs) bind to STAU1, a protein that binds to double-stranded RNA. Earlier studies defined the STAU1-binding site within ADP-ribosylation factor 1 (ARF1) mRNA as a 19-base-pair stem with a 100-nucleotide apex. However, we were unable to identify comparable structures in the 3' UTRs of other targets of SMD. Here we show that STAU1-binding sites can be formed by imperfect base-pairing between an Alu element in the 3' UTR of an SMD target and another Alu element in a cytoplasmic, polyadenylated long non-coding RNA (lncRNA). An individual lncRNA can downregulate a subset of SMD targets, and distinct lncRNAs can downregulate the same SMD target. These are previously unappreciated functions of non-coding RNAs and Alu elements. Not all mRNAs that contain an Alu element in the 3' UTR are targeted for SMD even in the presence of a complementary lncRNA that targets other mRNAs for SMD. Most known trans-acting RNA effectors consist of fewer than 200 nucleotides, and these include small nucleolar RNAs and microRNAs. Our finding that the binding of STAU1 to mRNAs can be transactivated by lncRNAs uncovers an unexpected strategy that cells use to recruit proteins to mRNAs and mediate the decay of these mRNAs. We name these lncRNAs half-STAU1-binding site RNAs (1/2-sbsRNAs).
	PMID: 21307942 [PubMed - indexed for MEDLINE]
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3.	Nature. 2011 Feb 10;470(7333):204-13. Charting a course for genomic medicine from base pairs to bedside. Green ED, Guyer MS; National Human Genome Research Institute. Collaborators: Green ED, Guyer MS, Manolio TA, Peterson JL. National Human Genome Research Institute, National Institutes of Health, 31 Center Dr., Bethesda, Maryland 20892-2152, USA. egreen@nhgri.nih.gov Abstract There has been much progress in genomics in the ten years since a draft sequence of the human genome was published. Opportunities for understanding health and disease are now unprecedented, as advances in genomics are harnessed to obtain robust foundational knowledge about the structure and function of the human genome and about the genetic contributions to human health and disease. Here we articulate a 2011 vision for the future of genomics research and describe the path towards an era of genomic medicine.
	PMID: 21307933 [PubMed - indexed for MEDLINE]
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4.	Nature. 2011 Feb 10;470(7333):198-203. A decade's perspective on DNA sequencing technology. Mardis ER. The Genome Center at Washington University School of Medicine, Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA. emardis@wustl.edu Abstract The decade since the Human Genome Project ended has witnessed a remarkable sequencing technology explosion that has permitted a multitude of questions about the genome to be asked and answered, at unprecedented speed and resolution. Here I present examples of how the resulting information has both enhanced our knowledge and expanded the impact of the genome on biomedical research. New sequencing technologies have also introduced exciting new areas of biological endeavour. The continuing upward trajectory of sequencing technology development is enabling clinical applications that are aimed at improving medical diagnosis and treatment.
	PMID: 21307932 [PubMed - indexed for MEDLINE]
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5.	Nature. 2011 Feb 10;470(7333):187-97. Initial impact of the sequencing of the human genome. Lander ES. Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA. lander@broadinstitute.org Abstract The sequence of the human genome has dramatically accelerated biomedical research. Here I explore its impact, in the decade since its publication, on our understanding of the biological functions encoded in the genome, on the biological basis of inherited diseases and cancer, and on the evolution and history of the human species. I also discuss the road ahead in fulfilling the promise of genomics for medicine.
	PMID: 21307931 [PubMed - indexed for MEDLINE]
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6.	Nature. 2011 Feb 10;470(7333):163-5. Too many roads not taken. Edwards AM, Isserlin R, Bader GD, Frye SV, Willson TM, Yu FH. University of Toronto, Toronto, Ontario M5G 1L7, Canada. aled.edwards@utoronto.ca
	PMID: 21307913 [PubMed - indexed for MEDLINE]
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7.	Nature. 2011 Feb 10;470(7333):161-2. Evolution: a can of worms. Maxmen A.
	PMID: 21307912 [PubMed - indexed for MEDLINE]
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8.	Nature. 2011 Feb 10;470(7333):155. Gene reading steps up a gear. Ledford H.
	PMID: 21307910 [PubMed - indexed for MEDLINE]
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9.	Nature. 2011 Feb 10;470(7333):140. Best is yet to come. [No authors listed]
	PMID: 21307 892 [PubMed - indexed for MEDLINE]
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