What's new for 'JKB_daily1' in PubMed

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Sender's message: Sepsis or genomics or altitude: JKB_daily1

Sent on Tuesday, 2011 Feb 22
Search (sepsis[MeSH Terms] OR septic shock[MeSH Terms] OR altitude[MeSH Terms] OR genomics[MeSH Terms] OR genetics[MeSH Terms] OR retrotransposons[MeSH Terms] OR macrophage[MeSH Terms]) AND ("2009/8/8"[Publication Date] : "3000"[Publication Date]) AND (("Science"[Journal] OR "Nature"[Journal] OR "The New England journal of medicine"[Journal] OR "Lancet"[Journal] OR "Nature genetics"[Journal] OR "Nature medicine"[Journal]) OR (Hume DA[Author] OR Baillie JK[Author] OR Faulkner, Geoffrey J[Author]))
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PubMed Results

Items 1 - 13 of 13

1.	Science. 2011 Feb 4;331(6017):548. Genome-sequencing anniversary. Painting the genome for the public. Cortada X.
	PMID: 21292969 [PubMed - indexed for MEDLINE]
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2.	Science. 2011 Feb 4;331(6017):548. Genome-sequencing anniversary. Bringing genomics and genetics back together. Gibbs RA. Department of Molecular and Human Genetics, Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
	PMID: 21292968 [PubMed - indexed for MEDLINE]
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3.	Science. 2011 Feb 4;331(6017):548. Genome-sequencing anniversary. What defines us? Cole-Turner R. Pittsburgh Theological Seminary, Pittsburgh, PA, USA.
	PMID: 21292967 [PubMed - indexed for MEDLINE]
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4.	Science. 2011 Feb 4;331(6017):547. Genome-sequencing anniversary. The golden age of human population genetics. Przeworski M. University of Chicago, Chicago, IL, USA.
	PMID: 21292966 [PubMed - indexed for MEDLINE]
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5.	Science. 2011 Feb 4;331(6017):547. Genome-sequencing anniversary. Genomics and clinical relevance. Hudson T. Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
	PMID: 21292965 [PubMed - indexed for MEDLINE]
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6.	Science. 2011 Feb 4;331(6017):546. Genome-sequencing anniversary. A celebration of the genome, part I. Jasny BR, Zahn LM.
	PMID: 21292964 [PubMed - indexed for MEDLINE]
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7.	Science. 2011 Feb 4;331(6017):546. Genome-sequencing anniversary. Faces of the genome. Collins FS. National Institutes of Health, Bethesda, MD, USA.
	PMID: 21292963 [PubMed - indexed for MEDLINE]
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8.	Science. 2011 Feb 4;331(6017):546-7. Genome-sequencing anniversary. The human genome at 10: successes and challen ges. Venter JC. J. Craig Venter Institute, Rockville, MD, USA.
	PMID: 21292962 [PubMed - indexed for MEDLINE]
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9.	Science. 2011 Feb 4;331(6017):530-1. Human genome 10th anniversary. The Human Genome (patent) Project. Kean S.
	PMID: 21292952 [PubMed - indexed for MEDLINE]
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10.	Science. 2011 Feb 4;331(6017):528-9. Human genome 10th anniversary. Human genetics in the clinic, one click away. Marshall E.
	PMID: 21292951 [PubMed - indexed for MEDLINE]
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11.	Science. 2011 Feb 4;331(6017):526-9. Human genome 10th anniversary. Waiting for the revolution. Marshall E.
	PMID: 21292950 [PubMed - indexed for MEDLINE]
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12.	Science. 2011 Feb 4;331(6017):511. Lessons from genomics. Alberts B. Free Article
	PMID: 21292941 [PubMed - indexed for MEDLINE]
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13.	Science. 2011 Feb 4;331(6017):593-6. Epub 2011 Jan 13. Aberrant overexpression of satellite rep eats in pancreatic and other epithelial cancers. Ting DT, Lipson D, Paul S, Brannigan BW, Akhavanfard S, Coffman EJ, Contino G, Deshpande V, Iafrate AJ, Letovsky S, Rivera MN, Bardeesy N, Maheswaran S, Haber DA. Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, MA 02114, USA. Abstract Satellite repeats in heterochromatin are transcribed into noncoding RNAs that have been linked to gene silencing and maintenance of chromosomal integrity. Using digital gene expression analysis, we showed that these transcripts are greatly overexpressed in mouse and human epithelial cancers. In 8 of 10 mouse pancreatic ductal adenocarcinomas (PDACs), pericentromeric satellites accounted for a mean 12% (range 1 to 50%) of all cellular transcripts, a mean 40-fold increase over that in normal tissue. In 15 of 15 human PDACs, alpha satellite transcripts were most abundant and HSATII transcripts were highly specific for cancer. Similar patterns were observed in cancers of the lung, kidney, ovary, colon, and prostate. Derepression of satellite transcripts correlated with overexpression of the long interspersed nuclear element 1 (LINE-1) retrotransposon and with aberrant expression of neuroendocrine-associated genes proximal to LINE-1 insertions. The overexpression of satellite transcripts in cancer may reflect global alterations in heterochromatin silencing and could potentially be useful as a biomarker for cancer detection.
	PMID: 21233348 [PubMed - indexed for MEDLINE]
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