What's new for 'JKB_daily1' in PubMed

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Sender's message: Sepsis or genomics or altitude: JKB_daily1

Sent on Tuesday, 2012 November 06
Search: (sepsis[MeSH Terms] OR septic shock[MeSH Terms] OR altitude[MeSH Terms] OR genomics[MeSH Terms] OR genetics[MeSH Terms] OR retrotransposons[MeSH Terms] OR macrophage[MeSH Terms]) AND ("2009/8/8"[Publication Date] : "3000"[Publication Date]) AND (("Science"[Journal] OR "Nature"[Journal] OR "The New England journal of medicine"[Journal] OR "Lancet"[Journal] OR "Nature genetics"[Journal] OR "Nature medicine"[Journal]) OR (Hume DA[Author] OR Baillie JK[Author] OR Faulkner, Geoffrey J[Author]))

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PubMed Results

Items 1 - 6 of 6

1.	Nature. 2012 Sep 13;489(7415):250-6. doi: 10.1038/nature11553. Genomic approaches to studying the human microbiota. Weinstock GM. The Genome Institute, Washington University, St. Louis, Missouri 63108, USA. gweinsto@genome.wustl.edu Abstract The human body is colonized by a vast array of microbes, which form communities of bacteria, viruses and microbial eukaryotes that are specific to each anatomical environment. Every community must be studied as a whole because many organisms have never been cultured independently, and this poses formidable challenges. The advent of next-generation DNA sequencing has allowed more sophisticated analysis and sampling of these complex systems by culture-independent methods. These methods are revealing differences in community structure between anatomical sites, between individuals, and between healthy and diseased states, and are transforming our view of human biology.
	PMID: 22972298 [PubMed - indexed for MEDLINE]
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2.	Nature. 2012 Sep 13;489(7415):219. doi: 10.1038/489219a. Gut microbes and health. Lupp C, Skipper M, Weiss U.
	PMID: 22972294 [PubMed - indexed for MEDLINE]
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3.	Nature. 2012 Sep 13;489(7415):208. doi: 10.1038/489208b. Genomics: ENCODE leads the way on big data. Gerstein M.
	PMID: 22972285 [PubMed - indexed for MEDLINE]
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4.	Nature. 2012 Sep 13;489(7415):194-6. doi: 10.1038/489194a. Deep-sea research: Dive master. Monastersky R.
	PMID: 22972276 [PubMed - indexed for MEDLINE]
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5.	Nat Genet. 2012 Jun 3;44(7):808-11. doi: 10.1038/ng.2309. Comparative population genomics of maize domestication and improvement. Hufford MB, Xu X, van Heerwaarden J, Pyhäjärvi T, Chia JM, Cartwright RA, Elshire RJ, Glaubitz JC, Guill KE, Kaeppler SM, Lai J, Morrell PL, Shannon LM, Song C, Springer NM, Swanson-Wagner RA, Tiffin P, Wang J, Zhang G, Doebley J, McMullen MD, Ware D, Buckler ES, Yang S, Ross-Ibarra J. Department of Plant Sciences, University of California, Davis, California, USA. Comment in A crop of maize variants. [Nat Genet. 2012] A crop of maize variants.Huang X, Han B. Nat Genet. 2012 Jun 27; 44(7):734-5. Epub 2012 Jun 27. Abstract Domestication and plant breeding are ongoing 10,000-year-old evolutionary experiments that have radically altered wild species to meet human needs. Maize has undergone a particularly striking transformation. Researchers have sought for decades to identify the genes underlying maize evolution, but these efforts have been limited in scope. Here, we report a comprehensive assessment of the evolution of modern maize based on the genome-wide resequencing of 75 wild, landrace and improved maize lines. We find evidence of recovery of diversity after domestication, likely introgression from wild relatives, and evidence for stronger selection during domestication than improvement. We identify a number of genes with stronger signals of selection than those previously shown to underlie major morphological changes. Finally, through transcriptome-wide analysis of gene expression, we find evidence both consistent with removal of cis-acting variation during maize domestication and improvement and suggestive of modern breeding having increased dominance in expression while targeting highly expressed genes.
	PMID: 22660546 [PubMed - indexed for MEDLINE]
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6.	Nat Genet. 2012 Jun 3;44(7):803-7. doi: 10.1038/ng.2313. Maize HapMap2 identifies extant variation from a genome in flux. Chia JM, Song C, Bradbury PJ, Costich D, de Leon N, Doebley J, Elshire RJ, Gaut B, Geller L, Glaubitz JC, Gore M, Guill KE, Holland J, Hufford MB, Lai J, Li M, Liu X, Lu Y, McCombie R, Nelson R, Poland J, Prasanna BM, Pyhäjärvi T, Rong T, Sekhon RS, Sun Q, Tenaillon MI, Tian F, Wang J, Xu X, Zhang Z, Kaeppler SM, Ross-Ibarra J, McMullen MD, Buckler ES, Zhang G, Xu Y, Ware D. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA. Comment in A crop of maize variants. [Nat Genet. 2012] A crop of maize variants.Huang X, Han B. Nat Genet. 2012 Jun 27; 44(7):734-5. Epub 2012 Jun 27. Abstract Whereas breeders have exploited diversity in maize for yield improvements, there has been limited progress in using beneficial alleles in undomesticated varieties. Characterizing standing variation in this complex genome has been challenging, with only a small fraction of it described to date. Using a population genetics scoring model, we identified 55 million SNPs in 103 lines across pre-domestication and domesticated Zea mays varieties, including a representative from the sister genus Tripsacum. We find that structural variations are pervasive in the Z. mays genome and are enriched at loci associated with important traits. By investigating the drivers of genome size variation, we find that the larger Tripsacum genome can be explained by transposable element abundance rather than an allopolyploid origin. In contrast, intraspecies genome size variation seems to be controlled by chromosomal knob content. There is tremendous overlap in key gene content in maize and Tripsacum, suggesting that adaptations from Tripsacum (for example, perennialism and frost and drought tolerance) can likely be integrated into maize.
	PMID: 22660545 [PubMed - indexed for MEDLINE]
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