What's new for 'JKB_daily1' in PubMed

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Sender's message: Sepsis or genomics or altitude: JKB_daily1

Sent on Friday, 2013 March 08
Search: (sepsis[MeSH Terms] OR septic shock[MeSH Terms] OR altitude[MeSH Terms] OR genomics[MeSH Terms] OR genetics[MeSH Terms] OR retrotransposons[MeSH Terms] OR macrophage[MeSH Terms]) AND ("2009/8/8"[Publication Date] : "3000"[Publication Date]) AND (("Science"[Journal] OR "Nature"[Journal] OR "The New England journal of medicine"[Journal] OR "Lancet"[Journal] OR "Nature genetics"[Journal] OR "Nature medicine"[Journal]) OR (Hume DA[Author] OR Baillie JK[Author] OR Faulkner, Geoffrey J[Author]))

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PubMed Results

Items 1 - 4 of 4

1.	Science. 2013 Mar 1;339(6123):1033. doi: 10.1126/science.339.6123.1033-a. Data re-identification: protect the children. Gurwitz D. Comment on Research ethics. The complexities of genomic identifiability. [Science. 2013] Research ethics. The complexities of genomic identifiability.Rodriguez LL, Brooks LD, Greenberg JH, Green ED. Science. 2013 Jan 18; 339(6117):275-6.
	PMID: 23449578 [PubMed - indexed for MEDLINE]
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2.	Science. 2013 Mar 1;339(6123):1032-3. doi: 10.1126/science.339.6123.1032-c. Data re-identification: societal safeguards. Altman RB, Clayton EW, Kohane IS, Malin BA, Roden DM. Comment on Identifying personal genomes by surname inference. [Science. 2013] Identifying personal genomes by surname inference.Gymrek M, McGuire AL, Golan D, Halperin E, Erlich Y. Science. 2013 Jan 18; 339(6117):321-4.
	PMID: 23449577 [PubMed - indexed for MEDLINE]
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3.	Science. 2013 Mar 1;339(6123):1030-1. doi: 10.1126/science.339.6123.1030. Environmental science. Pollutants capture the high ground in the Himalayas. Qiu J.
	PMID: 23449574 [PubMed - indexed for MEDLINE]
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4.	Science. 2013 Mar 1;339(6123):1077-80. doi: 10.1126/science.1233009. Epub 2013 Jan 24. Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO. Clark VE, Erson-Omay EZ, Serin A, Yin J, Cotney J, Ozduman K, Avşar T, Li J, Murray PB, Henegariu O, Yilmaz S, Günel JM, Carrión-Grant G, Yilmaz B, Grady C, Tanrikulu B, Bakircioğlu M, Kaymakçalan H, Caglayan AO, Sencar L, Ceyhun E, Atik AF, Bayri Y, Bai H, Kolb LE, Hebert RM, Omay SB, Mishra-Gorur K, Choi M, Overton JD, Holland EC, Mane S, State MW, Bilgüvar K, Baehring JM, Gutin PH, Piepmeier JM, Vortmeyer A, Brennan CW, Pamir MN, Kiliç T, Lifton RP, Noonan JP, Yasuno K, Günel M. Department of Neurosurgery, Yale Program in Brain Tumor Research, Yale School of Medicine, New Haven, CT 06510, USA. Abstract We report genomic analysis of 300 meningiomas, the most common primary brain tumors, leading to the discovery of mutations in TRAF7, a proapoptotic E3 ubiquitin ligase, in nearly one-fourth of all meningiomas. Mutations in TRAF7 commonly occurred with a recurrent mutation (K409Q) in KLF4, a transcription factor known for its role in inducing pluripotency, or with AKT1, a mutation known to activate the PI3K pathway. SMO mutations, which activate Hedgehog signaling, were identified in ~5% of non-NF2 mutant meningiomas. These non-NF2 meningiomas were clinically distinctive-nearly always benign, with chromosomal stability, and originating from the medial skull base. In contrast, meningiomas with mutant NF2 and/or chromosome 22 loss were more likely to be atypical, showing genomic instability, and localizing to the cerebral and cerebellar hemispheres. Collectively, these findings identify distinct meningioma subtypes, suggesting avenues for targeted therapeutics.
	PMID: 23348505 [PubMed - indexed for MEDLINE]
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