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Sender's message: Sepsis or genomics or altitude: JKB_daily1

Sent on Thursday, 2014 October 23
Search: (sepsis[MeSH Terms] OR septic shock[MeSH Terms] OR altitude[MeSH Terms] OR genomics[MeSH Terms] OR genetics[MeSH Terms] OR retrotransposons[MeSH Terms] OR macrophage[MeSH Terms]) AND ("2009/8/8"[Publication Date] : "3000"[Publication Date]) AND (("Science"[Journal] OR "Nature"[Journal] OR "The New England journal of medicine"[Journal] OR "Lancet"[Journal] OR "Nature genetics"[Journal] OR "Nature medicine"[Journal]) OR (Hume DA[Author] OR Baillie JK[Author] OR Faulkner, Geoffrey J[Author]))

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1.	N Engl J Med. 2014 Oct 9;371(15):1459-61. doi: 10.1056/NEJMe1408976. Epub 2014 Oct 1. Transfusion threshold of 7 g per deciliter--the new normal. Hébert PC1, Carson JL. Author information: 1From the Canadian Critical Care Trials Group, Department of Medicine and Centre de Recherche, Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal (P.C.H.); and the Division of General Internal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (J.L.C.). Comment on Lower versus higher hemoglobin threshold for transfusion in septic shock. [N Engl J Med. 2014] Lower versus higher hemoglobin threshold for transfusion in septic shock.Holst LB, Haase N, Wetterslev J, Wernerman J, Guttormsen AB, Karlsson S, Johansson PI, Aneman A, Vang ML, Winding R, et al. N Engl J Med. 2014 Oct 9; 371(15):1381-91. Epub 2014 Oct 1.
	PMID: 25270276 [PubMed - indexed for MEDLINE]
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2.	N Engl J Med. 2014 Oct 9;371(15):1381-91. doi: 10.1056/NEJMoa1406617. Epub 2014 Oct 1. Lower versus higher hemoglobin threshold for transfusion in septic shock. Holst LB1, Haase N, Wetterslev J, Wernerman J, Guttormsen AB, Karlsson S, Johansson PI, Aneman A, Vang ML, Winding R, Nebrich L, Nibro HL, Rasmussen BS, Lauridsen JR, Nielsen JS, Oldner A, Pettilä V, Cronhjort MB, Andersen LH, Pedersen UG, Reiter N, Wiis J, White JO, Russell L, Thornberg KJ, Hjortrup PB, Müller RG, Møller MH, Steensen M, Tjäder I, Kilsand K, Odeberg-Wernerman S, Sjøbø B, Bundgaard H, Thyø MA, Lodahl D, Mærkedahl R, Albeck C, Illum D, Kruse M, Winkel P, Perner A; TRISS Trial Group; Scandinavian Critical Care Trials Group. Collaborators: Holst LB, Haase N, Wernerman J, Guttormsen AB, Karlsson S, Johansson PI, Åneman A, Wetterslev J, Perner A, Holst LB, Wetterslev J, Perner A, Walsh T, Lacroix J, Fergusson D, De Backer D, Rowan K, Petersen JH, Holst LB, Perner A, Andersen LH, Pedersen U, Reiter N, Wiis J, White JO, Russell L, Thornberg KJ, Quist L, Ibsen M, Hjortrup PB, Müller RG, Møller MH, Steensen M, Claudius C, Kjær MN, Uhre KR, Christiansen V, Nislev LH, Sjøvall F, Jarnvig IL, Nielsen J, Thorsen HC, Bredahl P, Vang M, Bundgaard H, Thyø MA, Villumsen M, Wernerman J, Kilsand K, Tjäder I, Wernerman S, Winding R, Lodahl D, Mærkedahl R, Dey N, Haubjerg S, Nebrich L, Albeck C, Christensen A, Nibro H, Keld D, Larsen K, Dyrskog SE, Illum D, Rasmussen B, Granum SN, Bülow H, Elkjær J, Lauridsen J, Nielsen J, Guttormsen A, Sjøbø B, Oldner A, Friman O, Pettilä V, Pettilä L, Sutinen S, Cronhjort M, Kristensen B, Kirkegaard P, Lindhardt A, Strange D, Krogh EH, Rian O, Kruse M, Aagaard S, Pawlowicz MB, Madsen J, Poulsen L, Berezowicz P, Chew M, Abdeen F, Müller W, Sternheden G, Holmstrøm S, Thormar K, Mtchedlishvili N, Strand K, Karlsson S, Varila S, Kukkurainen A, Bendtsen A, Reinikainen M, Iversen S, Leivdal S, Bådstøløkken P, Longva J, Johansen R, Nielsen N, Breider J. Author information: 1From the Department of Intensive Care (L.B.H., N.H., L.H.A., U.G.P., N.R., J. Wiis, J.O.W., L.R., K.J.T., P.B.H., R.G.M., M.H.M., M.S., A.P.), Copenhagen Trial Unit, Center for Clinical Intervention Research (J. Wetterslev, P.W.), and Section for Transfusion Medicine (P.I.J.), Rigshospitalet and University of Copenhagen, Copenhagen, Randers Hospital, Randers (M.L.V., H.B., M.A.T.), Herning Hospital, Herning (R.W., D.L., R.M.), Hvidovre Hospital, Hvidovre (L.N., C.A.), Aarhus University Hospital, Aarhus (H.L.N., D.I.), Aalborg University Hospital, Aalborg (B.S.R.), Holbæk Hospital, Holbæk (J.R.M.L.), Kolding Hospital, Kolding (J.S.N.), and Hjørring Hospital, Hjørring (M.K.) - all in Denmark; Karolinska University Hospital, Huddinge, Stockholm (J. Wernerman, I.T., K.K., S.O.-W.), Karolinska University Hospital, Solna (A.O.), and Södersjukhuset, Stockholm (M.B.C.) - all in Sweden; Haukeland University Hospital and University of Bergen, Bergen, Norway (A.B.G., B.S.); Tampere University Hospital, Tampere (S.K.), and Helsinki University Hospital and University of Helsinki, Helsinki (V.P.) - all in Finland; and Liverpool Hospital, Sydney (A.Å.). Comment in Transfusion threshold of 7 g per deciliter--the new normal. [N Engl J Med. 2014] Transfusion threshold of 7 g per deciliter--the new normal.Hébert PC, Carson JL. N Engl J Med. 2014 Oct 9; 371(15):1459-61. Epub 2014 Oct 1. Abstract BACKGROUND: Blood transfusions are frequently given to patients with septic shock. However, the benefits and harms of different hemoglobin thresholds for transfusion have not been established. METHODS: In this multicenter, parallel-group trial, we randomly assigned patients in the intensive care unit (ICU) who had septic shock and a hemoglobin concentration of 9 g per deciliter or less to receive 1 unit of leukoreduced red cells when the hemoglobin level was 7 g per deciliter or less (lower threshold) or when the level was 9 g per deciliter or less (higher threshold) during the ICU stay. The primary outcome measure was death by 90 days after randomization. RESULTS: We analyzed data from 998 of 1005 patients (99.3%) who underwent randomization. The two intervention groups had similar baseline characteristics. In the ICU, the lower-threshold group received a median of 1 unit of blood (interquartile range, 0 to 3) and the higher-threshold group received a median of 4 units (interquartile range, 2 to 7). At 90 days after randomization, 216 of 502 patients (43.0%) assigned to the lower-threshold group, as compared with 223 of 496 (45.0%) assigned to the higher-threshold group, had died (relative risk, 0.94; 95% confidence interval, 0.78 to 1.09; P=0.44). The results were similar in analyses adjusted for risk factors at baseline and in analyses of the per-protocol populations. The numbers of patients who had ischemic events, who had severe adverse reactions, and who required life support were similar in the two intervention groups. CONCLUSIONS: Among patients with septic shock, mortality at 90 days and rates of ischemic events and use of life support were similar among those assigned to blood transfusion at a higher hemoglobin threshold and those assigned to blood transfusion at a lower threshold; the latter group received fewer transfusions. (Funded by the Danish Strategic Research Council and others; TRISS ClinicalTrials.gov number, NCT01485315.).
	PMID: 25270275 [PubMed - indexed for MEDLINE]
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