What's new for 'JKB_daily1' in PubMed

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Sender's message: Sepsis or genomics or altitude: JKB_daily1

Sent on Tuesday, 2014 February 25
Search: (sepsis[MeSH Terms] OR septic shock[MeSH Terms] OR altitude[MeSH Terms] OR genomics[MeSH Terms] OR genetics[MeSH Terms] OR retrotransposons[MeSH Terms] OR macrophage[MeSH Terms]) AND ("2009/8/8"[Publication Date] : "3000"[Publication Date]) AND (("Science"[Journal] OR "Nature"[Journal] OR "The New England journal of medicine"[Journal] OR "Lancet"[Journal] OR "Nature genetics"[Journal] OR "Nature medicine"[Journal]) OR (Hume DA[Author] OR Baillie JK[Author] OR Faulkner, Geoffrey J[Author]))

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PubMed Results

Items 1 - 4 of 4

1.	Science. 2014 Jan 24;343(6169):1236573. doi: 10.1126/science.1236573. A paleogenomic perspective on evolution and gene function: new insights from ancient DNA. Shapiro B1, Hofreiter M. Author information: 1Department of Ecology and Evolutionary Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA. Abstract The publication of partial and complete paleogenomes within the last few years has reinvigorated research in ancient DNA. No longer limited to short fragments of mitochondrial DNA, inference of evolutionary processes through time can now be investigated from genome-wide data sampled as far back as 700,000 years. Tremendous insights have been made, in particular regarding the hominin lineage. With rare exception, however, a paleogenomic perspective has been mired by the quality and quantity of recoverable DNA. Though conceptually simple, extracting ancient DNA remains challenging, and sequencing ancient genomes to high coverage remains prohibitively expensive for most laboratories. Still, with improvements in DNA isolation and declining sequencing costs, the taxonomic and geographic purview of paleogenomics is expanding at a rapid pace. With improved capacity to screen large numbers of samples for those with high proportions of endogenous ancient DNA, paleogenomics is poised to become a key technology to better understand recent evolutionary events.
	PMID: 24458647 [PubMed - indexed for MEDLINE]
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2.	Science. 2014 Jan 24;343(6169):437-40. doi: 10.1126/science.1247167. Transmissible dog cancer genome reveals the origin and history of an ancient cell lineage. Murchison EP1, Wedge DC, Alexandrov LB, Fu B, Martincorena I, Ning Z, Tubio JM, Werner EI, Allen J, De Nardi AB, Donelan EM, Marino G, Fassati A, Campbell PJ, Yang F, Burt A, Weiss RA, Stratton MR. Author information: 1Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK. Comment in Cancer. Hiding in plain view--an ancient dog in the modern world. [Science. 2014] Cancer. Hiding in plain view--an ancient dog in the modern world.Parker HG, Ostrander EA. Science. 2014 Jan 24; 343(6169):376-8. Abstract Canine transmissible venereal tumor (CTVT) is the oldest known somatic cell lineage. It is a transmissible cancer that propagates naturally in dogs. We sequenced the genomes of two CTVT tumors and found that CTVT has acquired 1.9 million somatic substitution mutations and bears evidence of exposure to ultraviolet light. CTVT is remarkably stable and lacks subclonal heterogeneity despite thousands of rearrangements, copy-number changes, and retrotransposon insertions. More than 10,000 genes carry nonsynonymous variants, and 646 genes have been lost. CTVT first arose in a dog with low genomic heterozygosity that may have lived about 11,000 years ago. The cancer spawned by this individual dispersed across continents about 500 years ago. Our results provide a genetic identikit of an ancient dog and demonstrate the robustness of mammalian somatic cells to survive for millennia despite a massive mutation burden. PMCID: PMC3918581 [Available on 2014/7/24]
	PMID: 24458646 [PubMed - indexed for MEDLINE]
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3.	Science. 2014 Jan 24;343(6169):361-3. doi: 10.1126/science.343.6169.361. The epigenetics heretic. Kaiser J.
	PMID: 24458620 [PubMed - indexed for MEDLINE]
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4.	Science. 2014 Jan 24;343(6169):356-7. doi: 10.1126/science.343.6169.356. Clinical research. Divulging DNA secrets of dead stirs debate. Couzin-Frankel J.
	PMID: 24458615 [PubMed - indexed for MEDLINE]
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