What's new for 'JKB_daily1' in PubMed

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Sender's message: Sepsis or genomics or altitude: JKB_daily1

Sent on Friday, 2014 April 11
Search: (sepsis[MeSH Terms] OR septic shock[MeSH Terms] OR altitude[MeSH Terms] OR genomics[MeSH Terms] OR genetics[MeSH Terms] OR retrotransposons[MeSH Terms] OR macrophage[MeSH Terms]) AND ("2009/8/8"[Publication Date] : "3000"[Publication Date]) AND (("Science"[Journal] OR "Nature"[Journal] OR "The New England journal of medicine"[Journal] OR "Lancet"[Journal] OR "Nature genetics"[Journal] OR "Nature medicine"[Journal]) OR (Hume DA[Author] OR Baillie JK[Author] OR Faulkner, Geoffrey J[Author]))

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PubMed Results

Items 1 - 2 of 2

1.	Science. 2014 Mar 28;343(6178):1439-40. doi: 10.1126/science.1252785. Immunology. The axis of tolerance. Aychek T1, Jung S. Author information: 1Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel. Comment on Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis. [Science. 2014] Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis.Mortha A, Chudnovskiy A, Hashimoto D, Bogunovic M, Spencer SP, Belkaid Y, Merad M. Science. 2014 Mar 28; 343(6178):1249288. Epub 2014 Mar 13.
	PMID: 24675941 [PubMed - indexed for MEDLINE]
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2.	Science. 2014 Mar 28;343(6178):1249288. doi: 10.1126/science.1249288. Epub 2014 Mar 13. Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis. Mortha A1, Chudnovskiy A, Hashimoto D, Bogunovic M, Spencer SP, Belkaid Y, Merad M. Author information: 1Department of Oncological Sciences, 1470 Madison Avenue, New York, NY 10029, USA. Comment in Immunology. The axis of tolerance. [Science. 2014] Immunology. The axis of tolerance.Aychek T, Jung S. Science. 2014 Mar 28; 343(6178):1439-40. Abstract The intestinal microbiota and tissue-resident myeloid cells promote immune responses that maintain intestinal homeostasis in the host. However, the cellular cues that translate microbial signals into intestinal homeostasis remain unclear. Here, we show that deficient granulocyte-macrophage colony-stimulating factor (GM-CSF) production altered mononuclear phagocyte effector functions and led to reduced regulatory T cell (T(reg)) numbers and impaired oral tolerance. We observed that RORγt(+) innate lymphoid cells (ILCs) are the primary source of GM-CSF in the gut and that ILC-driven GM-CSF production was dependent on the ability of macrophages to sense microbial signals and produce interleukin-1β. Our findings reveal that commensal microbes promote a crosstalk between innate myeloid and lymphoid cells that leads to immune homeostasis in the intestine.
	PMID: 24625929 [PubMed - indexed for MEDLINE]
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