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Sender's message: Sepsis or genomics or altitude: JKB_daily1

Sent on Tuesday, 2014 April 08
Search: (sepsis[MeSH Terms] OR septic shock[MeSH Terms] OR altitude[MeSH Terms] OR genomics[MeSH Terms] OR genetics[MeSH Terms] OR retrotransposons[MeSH Terms] OR macrophage[MeSH Terms]) AND ("2009/8/8"[Publication Date] : "3000"[Publication Date]) AND (("Science"[Journal] OR "Nature"[Journal] OR "The New England journal of medicine"[Journal] OR "Lancet"[Journal] OR "Nature genetics"[Journal] OR "Nature medicine"[Journal]) OR (Hume DA[Author] OR Baillie JK[Author] OR Faulkner, Geoffrey J[Author]))

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PubMed Results

Items 1 - 2 of 2

1.	Nat Med. 2014 Feb;20(2):108-9. doi: 10.1038/nm0214-108. Mystery disease sleuthing grows--with and without NIH funding. Dolgin E.
	PMID: 24504394 [PubMed - indexed for MEDLINE]
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2.	Nat Med. 2014 Feb;20(2):215-9. doi: 10.1038/nm.3437. Epub 2014 Jan 12. 2-deoxy-2-[18F]fluoro-D-mannose positron emission tomography imaging in atherosclerosis. Tahara N1, Mukherjee J2, de Haas HJ3, Petrov AD4, Tawakol A5, Haider N4, Tahara A6, Constantinescu CC, Zhou J, Boersma HH7, Imaizumi T6, Nakano M8, Finn A9, Fayad Z4, Virmani R8, Fuster V10, Bosca L11, Narula J4. Author information: 11] Kurume University School of Medicine, Kurume, Japan. [2]. 21] [2]. 31] Icahn School of Medicine at Mount Sinai, New York, New York, USA. [2] University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. [3]. 4Icahn School of Medicine at Mount Sinai, New York, New York, USA. 5Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, USA. 6Kurume University School of Medicine, Kurume, Japan. 7University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. 8CVPath Institute, Gaithersburg, Maryland, USA. 9Emory University School of Medicine, Atlanta, Georgia, USA. 101] Icahn School of Medicine at Mount Sinai, New York, New York, USA. [2] Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain. 11Instituto de Investigaciones Biomédicas Alberto Sols (Centro Mixto Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid), Madrid, Spain. Abstract Progressive inflammation in atherosclerotic plaques is associated with increasing risk of plaque rupture. Molecular imaging of activated macrophages with 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) has been proposed for identification of patients at higher risk for acute vascular events. Because mannose is an isomer of glucose that is taken up by macrophages through glucose transporters and because mannose receptors are expressed on a subset of the macrophage population in high-risk plaques, we applied (18)F-labeled mannose (2-deoxy-2-[(18)F]fluoro-D-mannose, [(18)F]FDM) for targeting of plaque inflammation. Here, we describe comparable uptake of [(18)F]FDM and [(18)F]FDG in atherosclerotic lesions in a rabbit model; [(18)F]FDM uptake was proportional to the plaque macrophage population. Our FDM competition studies in cultured cells with 2-deoxy-2-[(14)C]carbon-D-glucose ([(14)C]2DG) support at least 35% higher [(18)F]FDM uptake by macrophages in cell experiments. We also demonstrate that FDM restricts binding of anti-mannose receptor antibody to macrophages by approximately 35% and that mannose receptor targeting may provide an additional avenue for imaging of plaque inflammation.
	PMID: 24412923 [PubMed - indexed for MEDLINE]
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