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Sender's message: Sepsis or genomics or altitude: JKB_daily1

Sent on Wednesday, 2014 April 02
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PubMed Results

Item 1 of 1

1.	Nature. 2014 Mar 13;507(7491):225-8. doi: 10.1038/nature12960. Epub 2014 Jan 26. Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European. Olalde I1, Allentoft ME2, Sánchez-Quinto F3, Santpere G3, Chiang CW4, DeGiorgio M5, Prado-Martinez J3, Rodríguez JA3, Rasmussen S6, Quilez J3, Ramírez O3, Marigorta UM3, Fernández-Callejo M3, Prada ME7, Encinas JM8, Nielsen R9, Netea MG10, Novembre J11, Sturm RA12, Sabeti P13, Marquès-Bonet T14, Navarro A15, Willerslev E16, Lalueza-Fox C3. Author information: 11] Institut de Biologia Evolutiva, CSIC-UPF, Barcelona 08003, Spain [2]. 21] Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen K, Denmark [2]. 3Institut de Biologia Evolutiva, CSIC-UPF, Barcelona 08003, Spain. 4Department of Ecology and Evolutionary Biology, University of California, Los Angeles, California 90095, USA. 51] Department of Integrative Biology, University of California, Berkeley, California 94720, USA [2] Department of Biology, Pennsylvania State University, 502 Wartik Laboratory, University Park, Pennsylvania 16802, USA. 6Center for Biological Sequence Analysis, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark. 7I.E.S.O. 'Los Salados', Junta de Castilla y León, E-49600 Benavente, Spain. 8Junta de Castilla y León, Servicio de Cultura de León, E-24071 León, Spain. 9Center for Theoretical Evolutionary Genomics, University of California, Berkeley, California 94720, USA. 10Department of Medicine and Nijmegen Institute for Infection, Inflammation and Immunity, Radboud University Nijmegen Medical Centre, 6500 Nijmegen, The Netherlands. 11Department of Human Genetics, University of Chicago, Illinois 60637, USA. 12Institute for Molecular Bioscience, Melanogenix Group, The University of Queensland, Brisbane, Queensland 4072, Australia. 131] Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA [2] Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, USA. 141] Institut de Biologia Evolutiva, CSIC-UPF, Barcelona 08003, Spain [2] Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Catalonia, Spain. 151] Institut de Biologia Evolutiva, CSIC-UPF, Barcelona 08003, Spain [2] Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Catalonia, Spain [3] Centre de Regulació Genòmica (CRG), Barcelona 08003, Catalonia, Spain [4] National Institute for Bioinformatics (INB), Barcelona 08003, Catalonia, Spain. 16Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen K, Denmark. Abstract Ancient genomic sequences have started to reveal the origin and the demographic impact of farmers from the Neolithic period spreading into Europe. The adoption of farming, stock breeding and sedentary societies during the Neolithic may have resulted in adaptive changes in genes associated with immunity and diet. However, the limited data available from earlier hunter-gatherers preclude an understanding of the selective processes associated with this crucial transition to agriculture in recent human evolution. Here we sequence an approximately 7,000-year-old Mesolithic skeleton discovered at the La Braña-Arintero site in León, Spain, to retrieve a complete pre-agricultural European human genome. Analysis of this genome in the context of other ancient samples suggests the existence of a common ancient genomic signature across western and central Eurasia from the Upper Paleolithic to the Mesolithic. The La Braña individual carries ancestral alleles in several skin pigmentation genes, suggesting that the light skin of modern Europeans was not yet ubiquitous in Mesolithic times. Moreover, we provide evidence that a significant number of derived, putatively adaptive variants associated with pathogen resistance in modern Europeans were already present in this hunter-gatherer.
	PMID: 24463515 [PubMed - indexed for MEDLINE]