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Sender's message: Sepsis or genomics or altitude: JKB_daily1

Sent on Saturday, 2014 November 08
Search: (sepsis[MeSH Terms] OR septic shock[MeSH Terms] OR altitude[MeSH Terms] OR genomics[MeSH Terms] OR genetics[MeSH Terms] OR retrotransposons[MeSH Terms] OR macrophage[MeSH Terms]) AND ("2009/8/8"[Publication Date] : "3000"[Publication Date]) AND (("Science"[Journal] OR "Nature"[Journal] OR "The New England journal of medicine"[Journal] OR "Lancet"[Journal] OR "Nature genetics"[Journal] OR "Nature medicine"[Journal]) OR (Hume DA[Author] OR Baillie JK[Author] OR Faulkner, Geoffrey J[Author]))

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1.	Nature. 2014 Sep 25;513(7519):501-6. doi: 10.1038/nature13704. Epub 2014 Sep 14. Asian monsoons in a late Eocene greenhouse world. Licht A1, van Cappelle M2, Abels HA3, Ladant JB4, Trabucho-Alexandre J5, France-Lanord C6, Donnadieu Y4, Vandenberghe J7, Rigaudier T6, Lécuyer C 8, Terry D Jr9, Adriaens R10, Boura A11, Guo Z12, Soe AN13, Quade J14, Dupont-Nivet G15, Jaeger JJ16. Author information: 11] Institut de Paléoprimatologie, Paléontologie Humaine: Evolution et Paléoenvironnements, UMR CNRS 7262, Université de Poitiers, 86000 Poitiers, France [2] Centre de Recherches Pétrographiques et Géochimiques, UMR CNRS 7358, Université de Lorraine 54501 Vandoeuvre les Nancy, France [3] Department of Geosciences, University of Arizona, Tucson, Arizona 85721, USA. 21] Department of Earth Sciences, Universiteit Utrecht, 3584CD, Utrecht, The Netherlands [2] Department of Earth Science and Engineering, Imperial College London, London SW7 2AZ, UK. 31] Department of Earth Sciences, Universiteit Utrecht, 3584CD, Utrecht, The Netherlands [2] Department of Earth and Environmental Sciences, Katholieke Universiteit Leuven, 3001 Leuven, Belgium. 4Laboratoire des Sciences du Climat et de l'Environnement, UMR CNRS 8212, 91198 Gif-sur-Yvette, France. 5Department of Earth Sciences, Durham University, Durham DH1 3LE, UK. 6Centre de Recherches Pétrographiques et Géochimiques, UMR CNRS 7358, Université de Lorraine 54501 Vandoeuvre les Nancy, France. 7Department of Earth Sciences, Vrije Universiteit, 1081HV Amsterdam, The Netherlands. 8Laboratoire de Géologie de Lyon, Terre, Planètes, Environnement, UMR CNRS 5276, Université de Lyon, Institut Universitaire de France, 69622 Lyon, France. 9Department of Earth and Environmental Science, Temple University, Philadelphia, Pennsylvania 19122, USA. 10Department of Earth and Environmental Sciences, Katholieke Universiteit Leuven, 3001 Leuven, Belgium. 11Centre de Recherche sur la Paléodiversité et les Paléoenvironnements - UPMC, MNHN, CNRS, 75005 Paris, France. 12Key Laboratory of Orogenic Belts and Crustal Evolution, Peking University, 100871 Beijing, China. 13Department of Geology, Defence Services Academy, Pyin Oo Lwin, Myanmar. 14Department of Geosciences, University of Arizona, Tucson, Arizona 85721, USA. 151] Department of Earth Sciences, Universiteit Utrecht, 3584CD, Utrecht, The Netherlands [2] Key Laboratory of Orogenic Belts and Crustal Evolution, Peking University, 100871 Beijing, China [3] Géosciences Rennes, UMR CNRS 6118, Université de Rennes, 35042 Rennes Cedex, France [4] Universität Potsdam, Institute of Earth and Environmental Science, 14476 Potsdam, Germany. 16Institut de Paléoprimatologie, Paléontologie Humaine: Evolution et Paléoenvironnements, UMR CNRS 7262, Université de Poitiers, 86000 Poitiers, France. Abstract The strong present-day Asian monsoons are thought to have originated between 25 and 22 million years (Myr) ago, driven by Tibetan-Himalayan uplift. However, the existence of older Asian monsoons and their response to enhanced greenhouse conditions such as those in the Eocene period (55-34 Myr ago) are unknown because of the paucity of well-dated records. Here we show late Eocene climate records revealing marked monsoon-like patterns in rainfall and wind south and north of the Tibetan-Himalayan orogen. This is indicated by low oxygen isotope values with strong seasonality in gastropod shells and mammal teeth from Myanmar, and by aeolian dust deposition in northwest China. Our climate simulations support modern-like Eocene monsoonal rainfall and show that a reinforced hydrological cycle responding to enhanced greenhouse conditions counterbalanced the negative effect of lower Tibetan relief on precipitation. These strong monsoons later weakened with the global shift to icehouse conditions 34 Myr ago.
	PMID: 25219854 [PubMed - indexed for MEDLINE]
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2.	Nature. 2014 Sep 25;513(7519):559-63. doi: 10.1038/nature13490. Epub 2014 Jul 13. Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. Colegio OR1, Chu NQ2, Szabo AL2, Chu T2, Rhebergen AM2, Jairam V2, Cyrus N2, Brokowski CE2, Eisenbarth SC3, Phillips GM4, Cline GW5, Phillips AJ4, Medzhitov R6. Author information: 11] Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06519-1612, USA [2] Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520-8059, USA [3] Yale-New Haven Transplantation Center, Yale University School of Medicine, New Haven, Connecticut 06519-1369, USA [4] Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut 06520-8028, USA. 2Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06519-1612, USA. 31] Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06519-1612, USA [2] Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8035, USA. 4Department of Chemistry, Yale University School of Medicine, New Haven, Connecticut 06520-8107, USA. 5Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8020, USA. 61] Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06519-1612, USA [2] Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut 06520-8028, USA [3] Howard Hughes Medical Institute, Chevy Chase, Maryland 20815-6789, USA. Comment in Tumor cells hijack macrophages via lactic acid. [Immunol Cell Biol. 2014] Tumor cells hijack macrophages via lactic acid.Bronte V. Immunol Cell Biol. 2014 Sep; 92(8):647-9. Epub 2014 Aug 5. Abstract Macrophages have an important role in the maintenance of tissue homeostasis. To perform this function, macrophages must have the capacity to monitor the functional states of their 'client cells': namely, the parenchymal cells in the various tissues in which macrophages reside. Tumours exhibit many features of abnormally developed organs, including tissue architecture and cellular composition. Similarly to macrophages in normal tissues and organs, macrophages in tumours (tumour-associated macrophages) perform some key homeostatic functions that allow tumour maintenance and growth. However, the signals involved in communication between tumours and macrophages are poorly defined. Here we show that lactic acid produced by tumour cells, as a by-product of aerobic or anaerobic glycolysis, has a critical function in signalling, through inducing the expression of vascular endothelial growth factor and the M2-like polarization of tumour-associated macrophages. Furthermore, we demonstrate that this effect of lactic acid is mediated by hypoxia-inducible factor 1α (HIF1α). Finally, we show that the lactate-induced expression of arginase 1 by macrophages has an important role in tumour growth. Collectively, these findings identify a mechanism of communication between macrophages and their client cells, including tumour cells. This communication most probably evolved to promote homeostasis in normal tissues but can also be engaged in tumours to promote their growth.
	PMID: 25043024 [PubMed - indexed for MEDLINE]
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