What's new for 'JKB_daily1' in PubMed

This message contains My NCBI what's new results from the National Center for Biotechnology Information (NCBI) at the U.S. National Library of Medicine (NLM).
Do not reply directly to this message.

Sender's message: Sepsis or genomics or altitude: JKB_daily1

Sent on Thursday, 2014 December 18
Search: (sepsis[MeSH Terms] OR septic shock[MeSH Terms] OR altitude[MeSH Terms] OR genomics[MeSH Terms] OR genetics[MeSH Terms] OR retrotransposons[MeSH Terms] OR macrophage[MeSH Terms]) AND ("2009/8/8"[Publication Date] : "3000"[Publication Date]) AND (("Science"[Journal] OR "Nature"[Journal] OR "The New England journal of medicine"[Journal] OR "Lancet"[Journal] OR "Nature genetics"[Journal] OR "Nature medicine"[Journal]) OR (Hume DA[Author] OR Baillie JK[Author] OR Faulkner, Geoffrey J[Author]))

View complete results in PubMed (results may change over time).

Edit saved search settings, or unsubscribe from these e-mail updates.

PubMed Results

Items 1 - 4 of 4

1.	Nat Med. 2014 Oct;20(10):1124-5. doi: 10.1038/nm.3696. Lasker Award winner Mary-Claire King. King MC.
	PMID: 25295950 [PubMed - indexed for MEDLINE]
	Related citations

2.	Nat Med. 2014 Oct;20(10):1103-4. doi: 10.1038/nm.3722. Genome editing: a tool for research and therapy: towards a functional understanding of variants for molecular diagnostics using genome editing. Tsai SQ1, Iafrate AJ1, Joung JK1.
	PMID: 25295940 [PubMed - indexed for MEDLINE]
	Related citations

3.	Nat Med. 2014 Oct;20(10):1082-3. doi: 10.1038/nm1014-1082. New platform for cataloging hundreds of proteins gets test drive. Powell K.
	PMID: 25295926 [PubMed - indexed for MEDLINE]
	Related citations

4.	Nat Med. 2014 Oct;20(10):1211-6. doi: 10.1038/nm.3640. Epub 2014 Sep 14. An extracorporeal blood-cleansing device for sepsis therapy. Kang JH1, Super M2, Yung CW3, Cooper RM4, Domansky K5, Graveline AR5, Mammoto T6, Berthet JB5, Tobin H6, Cartwright MJ5, Watters AL5, Rottman M2, Waterhouse A5, Mammoto A6, Gamini N5, Rodas MJ5, Kole A5, Jiang A6, Valentin TM5, Diaz A5, Takahashi K7, Ingber DE8. Abstract Here we describe a blood-cleansing device for sepsis therapy inspired by the spleen, which can continuously remove pathogens and toxins from blood without first identifying the infectious agent. Blood flowing from an infected individual is mixed with magnetic nanobeads coated with an engineered human opsonin--mannose-binding lectin (MBL)--that captures a broad range of pathogens and toxins without activating complement factors or coagulation. Magnets pull the opsonin-bound pathogens and toxins from the blood; the cleansed blood is then returned back to the individual. The biospleen efficiently removes multiple Gram-negative and Gram-positive bacteria, fungi and endotoxins from whole human blood flowing through a single biospleen unit at up to 1.25 liters per h in vitro. In rats infected with Staphylococcus aureus or Escherichia coli, the biospleen cleared >90% of bacteria from blood, reduced pathogen and immune cell infiltration in multiple organs and decreased inflammatory cytokine levels. In a model of endotoxemic shock, the biospleen increased survival rates after a 5-h treatment.
	PMID: 25216635 [PubMed - indexed for MEDLINE]
	Related citations