What's new for 'JKB_daily1' in PubMed

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Sender's message: Sepsis or genomics or altitude: JKB_daily1

Sent on Saturday, 2014 November 15
Search: (sepsis[MeSH Terms] OR septic shock[MeSH Terms] OR altitude[MeSH Terms] OR genomics[MeSH Terms] OR genetics[MeSH Terms] OR retrotransposons[MeSH Terms] OR macrophage[MeSH Terms]) AND ("2009/8/8"[Publication Date] : "3000"[Publication Date]) AND (("Science"[Journal] OR "Nature"[Journal] OR "The New England journal of medicine"[Journal] OR "Lancet"[Journal] OR "Nature genetics"[Journal] OR "Nature medicine"[Journal]) OR (Hume DA[Author] OR Baillie JK[Author] OR Faulkner, Geoffrey J[Author]))

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1.	N Engl J Med. 2014 Nov 6;371(19):1833-7. doi: 10.1056/NEJMcps1313772. Clinical problem-solving. A chilly fever. Price C, Ashbaugh C, Miller AL, Loscalzo J.
	PMID: 25372092 [PubMed - indexed for MEDLINE]
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2.	Science. 2014 Oct 31;346(6209):641-6. doi: 10.1126/science.1258705. Innate immunity. A Spaetzle-like role for nerve growth factor β in vertebrate immunity to Staphylococcus aureus. Hepburn L1, Prajsnar TK2, Klapholz C1, Moreno P3, Loynes CA4, Ogryzko NV5, Brown K6, Schiebler M1, Hegyi K1, Antrobus R3, Hammond KL4, Connolly J7, Ochoa B8, Bryant C9, Otto M10, Surewaard B11, Seneviratne SL12, Grogono DM13, Cachat J14, Ny T15, Kaser A16, Török ME16, Peacock SJ17, Holden M18, Blundell T8, Wang L19, Ligoxygakis P19, Minichiello L20, Woods CG21, Foster SJ7, Renshaw SA22, Floto RA23. Author information: 1Cambridge Institute for Medical Research, University of Cambridge, UK. Department of Medicine, University of Cambridge, UK. 2Krebs Institute, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK. Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK. Bateson Centre, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK. 3Cambridge Institute for Medical Research, University of Cambridge, UK. 4Bateson Centre, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK. Department of Infection and Immunity, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK. 5Bateson Centre, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK. 6Cambridge Institute for Medical Research, University of Cambridge, UK. Department of Medicine, University of Cambridge, UK. Cambridge Centre for Lung Infection, Papworth Hospital, Cambridge, UK. 7Krebs Institute, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK. Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK. 8Department of Biochemistry, University of Cambridge, UK. 9Department of Veterinary Medicine, University of Cambridge, UK. 10Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, USA. 11Department of Medical Microbiology, University Medical Centre, Utrecht, Netherlands. 12Department of Clinical Immunology, Royal Free Hospital London, UK. 13Department of Medicine, University of Cambridge, UK. Cambridge Centre for Lung Infection, Papworth Hospital, Cambridge, UK. 14Department of Pathology and Immunology, Geneva University, Switzerland. 15Department of Medical Biochemistry and Biophysics, Umea University, Sweden. 16Department of Medicine, University of Cambridge, UK. 17Department of Medicine, University of Cambridge, UK. Wellcome Trust Sanger Institute, Hinxton, UK. 18Wellcome Trust Sanger Institute, Hinxton, UK. School of Medicine, University of St. Andrews, UK. 19Biochemistry Department, Oxford University, UK. 20Pharmacology Department, Oxford University, UK. 21Cambridge Institute for Medical Research, University of Cambridge, UK. Department of Medical Genetics, University of Cambridge, UK. 22Krebs Institute, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK. Bateson Centre, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK. Department of Infection and Immunity, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK. arf27@cam.ac.uk s.a.renshaw@sheffield.ac.uk. 23Cambridge Institute for Medical Research, University of Cambridge, UK. Department of Medicine, University of Cambridge, UK. Cambridge Centre for Lung Infection, Papworth Hospital, Cambridge, UK. arf27@cam.ac.uk s.a.renshaw@sheffield.ac.uk. Abstract Many key components of innate immunity to infection are shared between Drosophila and humans. However, the fly Toll ligand Spaetzle is not thought to have a vertebrate equivalent. We have found that the structurally related cystine-knot protein, nerve growth factor β (NGFβ), plays an unexpected Spaetzle-like role in immunity to Staphylococcus aureus infection in chordates. Deleterious mutations of either human NGFβ or its high-affinity receptor tropomyosin-related kinase receptor A (TRKA) were associated with severe S. aureus infections. NGFβ was released by macrophages in response to S. aureus exoproteins through activation of the NOD-like receptors NLRP3 and NLRP4 and enhanced phagocytosis and superoxide-dependent killing, stimulated proinflammatory cytokine production, and promoted calcium-dependent neutrophil recruitment. TrkA knockdown in zebrafish increased susceptibility to S. aureus infection, confirming an evolutionarily conserved role for NGFβ-TRKA signaling in pathogen-specific host immunity. Copyright © 2014, American Association for the Advancement of Science.
	PMID: 25359976 [PubMed - indexed for MEDLINE]
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