What's new for 'JKB_daily1' in PubMed

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Sender's message: Sepsis or genomics or altitude: JKB_daily1

Sent on Wednesday, 2010 Apr 07
Search (sepsis[MeSH Terms] OR septic shock[MeSH Terms] OR altitude[MeSH Terms] OR genomics[MeSH Terms] OR genetics[MeSH Terms] OR retrotransposons[MeSH Terms] OR macrophage[MeSH Terms]) AND ("2009/8/8"[Publication Date] : "3000"[Publication Date]) AND (("Science"[Journal] OR "Nature"[Journal] OR "The New England journal of medicine"[Journal] OR "Lancet"[Journal] OR "Nature genetics"[Journal] OR "Nature medicine"[Journal]) OR (Hume DA[Author] OR Baillie JK[Author] OR Faulkner, Geoffrey J[Author]))
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1.	Science. 2010 Mar 19;327(5972):1463-5. Neuroscience. AMPA receptors--another twist? Farrant M, Cull-Candy SG. Department of Neuroscience, Physiology, and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK. m.farrant@ucl.ac.uk Comment on: Science. 2010 Mar 19;327(5972):1518-22.
	PMID: 20299582 [PubMed - indexed for MEDLINE]
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	Publication Types: Comment Research Support, Non-U.S. Gov't MeSH Terms: Animals CA1 Region, Hippocampal/cytology CA1 Region, Hippocampal/metabolism* Dendritic Spines/metabolism Dentate Gyrus/cytology Dentate Gyrus/metabolism* Excitatory Postsynaptic Potentials Membrane Proteins/metabolism Mice Miniature Postsynaptic Potentials Nerve Tissue Proteins/chemistry Nerve Tissue Proteins/metabolism* Neuronal Plasticity* Neurons/metabolism* Protein Interaction Domains and Motifs Protein Structure, Tertiary Proteomics Pyramidal Cells/metabolism Receptors, AMPA/chemistry Receptors, AMPA/metabolism* Synapses/physiology* Synaptic Transmission* Substances: CKAMP44 protein, mouse Membrane Proteins Nerve Tissue Proteins Receptors, AMPA Grant Support: Wellcome Trust/United Kingdom

2.	Science. 2010 Mar 19;327(5972):1518-22. Epub 2010 Feb 25. CKAMP44: a brain-specific protein attenuating short-term synaptic plasticity in the dentate gyrus. von Engelhardt J, Mack V, Sprengel R, Kavenstock N, Li KW, Stern-Bach Y, Smit AB, Seeburg PH, Monyer H. Department of Clinical Neurobiology, University of Heidelberg, 6910 Heidelberg, Germany. Comment in: Science. 2010 Mar 19;327(5972):1463-5. Abstract CKAMP44, identified here by a proteomic approach, is a brain-specific type I transmembrane protein that associates with AMPA receptors in synaptic spines. CKAMP44 expressed in Xenopus oocytes reduced GluA1- and A2-mediated steady-state currents, but did not affect kainate- or N-methyl-D-aspartate (NMDA) receptor-mediated currents. Mouse hippocampal CA1 pyramidal neurons expressed CKAMP44 at low abundance, and overexpression of CKAMP44 led to stronger and faster AMPA receptor desensitization, slower recovery from desensitization, and a reduction in the paired-pulse ratio of AMPA currents. By contrast, dentate gyrus granule cells exhibited strong CKAMP44 expression, and CKAMP44 knockout increased the paired-pulse ratio of AMPA currents in lateral and medial perforant path-granule cell synapses. CKAMP44 thus modulates short-term plasticity at specific excitatory synapses.
	PMID: 20185686 [PubMed - indexed for MEDLINE]
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	Publication Types: Research Support, Non-U.S. Gov't MeSH Terms: Animals CA1 Region, Hippocampal/metabolism Calcium Channels/metabolism Dendritic Spines/metabolism Dentate Gyrus/cytology Dentate Gyrus/metabolism* Excitatory Postsynaptic Potentials Glutamic Acid/metabolism Intracellular Signaling Peptides and Proteins/metabolism Membrane Proteins/metabolism Mice Mice, Knockout Miniature Postsynaptic Potentials Molecular Sequence Data Nerve Tissue Proteins/chemistry Nerve Tissue Proteins/genetics Nerve Tissue Proteins/metabolism* Neural Inhibition Neuronal Plasticity* Neurons/metabolism* Oocytes/metabolism Patch-Clamp Techniques Perforant Pathway Protein Interaction Domains and Motifs Protein Isoforms/genetics Protein Isoforms/metabolism Proteomics Pyramidal Cells/metabolism Receptors, AMPA/chemistry Receptors, AMPA/metabolism* Recombinant Fusion Proteins/metabolism Reverse Transcriptase Polymerase Chain Reaction Synapses/physiology* Synaptic Transmission* Xenopus laevis Substances: CKAMP44 protein, mouse Cacng2 protein, mouse Calcium Channels Dlgh4 protein, mouse Intracellular Signaling Peptides and Proteins Membrane Proteins Nerve Tissue Proteins Protein Isoforms Receptors, AMPA Recombinant Fusion Proteins Glutamic Acid Secondary Source ID: GENBANK/GU479981 GENBANK/GU479982