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Sender's message: Sepsis or genomics or altitude: JKB_daily1

Sent on Friday, 2010 Apr 16
Search (sepsis[MeSH Terms] OR septic shock[MeSH Terms] OR altitude[MeSH Terms] OR genomics[MeSH Terms] OR genetics[MeSH Terms] OR retrotransposons[MeSH Terms] OR macrophage[MeSH Terms]) AND ("2009/8/8"[Publication Date] : "3000"[Publication Date]) AND (("Science"[Journal] OR "Nature"[Journal] OR "The New England journal of medicine"[Journal] OR "Lancet"[Journal] OR "Nature genetics"[Journal] OR "Nature medicine"[Journal]) OR (Hume DA[Author] OR Baillie JK[Author] OR Faulkner, Geoffrey J[Author]))
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1.	Nat Genet. 2010 Mar;42(3):210-5. Epub 2010 Feb 7. Genome-wide association study of hematological and biochemical traits in a Japanese population. Kamatani Y, Matsuda K, Okada Y, Kubo M, Hosono N, Daigo Y, Nakamura Y, Kamatani N. Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, the University of Tokyo, Tokyo, Japan. Abstract We report genome-wide association studies for hematological and biochemical traits from approximately 14,700 Japanese individuals. We identified 60 associations for 8 hematological traits and 29 associations for 12 biochemical traits at genome-wide significance levels (P < 5 x 10(-8)). Of these, 46 associations were new to this study and 43 replicated previous reports. We compared these associated loci with those reported in similar GWAS in European populations. When the minor allele frequency was >10% in the Japanese population, 32 (94.1%) and 31 (91.2%) of the 34 hematological loci previously reported to be associated in a European population were replicated with P-values less than 0.05 and 0.01, respectively, and 31 (73.8%) and 27 (64.3%) of the 42 European biochemical loci were replicated.
	PMID: 20139978 [PubMed - indexed for MEDLINE]
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	Publication Types: Research Support, Non-U.S. Gov't MeSH Terms: Asian Continental Ancestry Group/genetics* Biological Markers/analysis Biological Markers/blood* Blood Cell Count Blood Chemical Analysis Cohort Studies Erythrocytes/cytology Erythrocytes/pathology Gene Frequency Genetics, Population Genome-Wide Association Study* Hematologic Diseases/blood Hematologic Diseases/genetics Hematologic Diseases/pathology Hematologic Tests Humans Polymorphism, Single Nucleotide Quantitative Trait Loci* Uric Acid/blood Substances: Biological Markers Uric Acid

2.	Nat Genet. 2010 Mar;42(3):260-3. Epub 2010 Jan 24. Population resequencing reveals local adaptation of Arabidopsis lyrata to serpentine soils. Turner TL, Bourne EC, Von Wettberg EJ, Hu TT, Nuzhdin SV. Molecular and Computational Biology, University of Southern California, Los Angeles, California, USA. tturner@lifesci.ucsb.edu Abstract A powerful way to map functional genomic variation and reveal the genetic basis of local adaptation is to associate allele frequency across the genome with environmental conditions. Serpentine soils, characterized by high heavy-metal content and low calcium-to-magnesium ratios, are a classic context for studying adaptation of plants to local soil conditions. To investigate whether Arabidopsis lyrata is locally adapted to serpentine soil, and to map the polymorphisms responsible for such adaptation, we pooled DNA from individuals from serpentine and nonserpentine soils and sequenced each 'gene pool' with the Illumina Genome Analyzer. The polymorphisms that are most strongly associated with soil type are enriched at heavy-metal detoxification and calcium and magnesium transport loci, providing numerous candidate mutations for serpentine adaptation. Sequencing of three candidate loci in the European subspecies of A. lyrata indicates parallel differentiation of the same polymorphism at one locus, confirming ecological adaptation, and different polymorphisms at two other loci, which may indicate convergent evolution.
	PMID: 20101244 [PubMed - indexed for MEDLINE]
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	Publication Types: Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. MeSH Terms: Adaptation, Biological/drug effects Adaptation, Biological/genetics* Arabidopsis/genetics* Arabidopsis/physiology Asbestos, Serpentine/pharmacology* DNA, Plant/analysis DNA, Plant/drug effects Evolution, Molecular Genes, Plant/drug effects Genetics, Population Genome, Plant/drug effects Geography Metals, Heavy/pharmacology Microsatellite Repeats/genetics Polymorphism, Genetic Sequence Analysis, DNA*/methods Soil* Substances: Asbestos, Serpentine DNA, Plant Metals, Heavy Soil Grant Support: RGM-076643/PHS HHS/United States