What's new for 'JKB_daily1' in PubMed

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Sender's message: Sepsis or genomics or altitude: JKB_daily1

Sent on Wednesday, 2010 May 05
Search (sepsis[MeSH Terms] OR septic shock[MeSH Terms] OR altitude[MeSH Terms] OR genomics[MeSH Terms] OR genetics[MeSH Terms] OR retrotransposons[MeSH Terms] OR macrophage[MeSH Terms]) AND ("2009/8/8"[Publication Date] : "3000"[Publication Date]) AND (("Science"[Journal] OR "Nature"[Journal] OR "The New England journal of medicine"[Journal] OR "Lancet"[Journal] OR "Nature genetics"[Journal] OR "Nature medicine"[Journal]) OR (Hume DA[Author] OR Baillie JK[Author] OR Faulkner, Geoffrey J[Author]))
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PubMed Results

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1.	Science. 2010 Apr 23;328(5977):508-12. Dysregulated humoral immunity to nontyphoidal Salmonella in HIV-infected African adults. MacLennan CA, Gilchrist JJ, Gordon MA, Cunningham AF, Cobbold M, Goodall M, Kingsley RA, van Oosterhout JJ, Msefula CL, Mandala WL, Leyton DL, Marshall JL, Gondwe EN, Bobat S, López-Macías C, Doffinger R, Henderson IR, Zijlstra EE, Dougan G, Drayson MT, MacLennan IC, Molyneux ME. Medical Research Council Centre for Immune Regulation and Clinical Immunology Service, Institute of Biomedical Research, School of Immunity and Infection, University of Birmingham, Birmingham, UK. c.maclennan@bham.ac.uk Comment in: Science. 2010 Apr 23;328(5977):439-40. Abstract Nontyphoidal Salmonellae are a major cause of life-threatening bacteremia among HIV-infected individuals. Although cell-mediated immunity controls intracellular infection, antibodies protect against Salmonella bacteremia. We report that high-titer antibodies specific for Salmonella lipopolysaccharide (LPS) are associated with a lack of Salmonella-killing in HIV-infected African adults. Killing was restored by genetically shortening LPS from the target Salmonella or removing LPS-specific antibodies from serum. Complement-mediated killing of Salmonella by healthy serum is shown to be induced specifically by antibodies against outer membrane proteins. This killing is lost when excess antibody against Salmonella LPS is added. Thus, our study indicates that impaired immunity against nontyphoidal Salmonella bacteremia in HIV infection results from excess inhibitory antibodies against Salmonella LPS, whereas serum killing of Salmonella is induced by antibodies against outer membrane proteins.
	PMID: 20413503 [PubMed - indexed for MEDLINE]
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	Publication Types: Research Support, Non-U.S. Gov't MeSH Terms: AIDS-Related Opportunistic Infections/immunology Adult Animals Antibodies, Bacterial/blood Antibodies, Bacterial/immunology* Antibodies, Blocking/blood Antibodies, Blocking/immunology* Bacteremia/immunology Bacterial Outer Membrane Proteins/immunology* Complement Activation Disease Susceptibility HIV Infections/complications HIV Infections/immunology* Humans Immunoglobulin G/blood Immunoglobulin G/immunology Lipopolysaccharides/blood Lipopolysaccharides/immunology* Malawi Mice Mutation O Antigens/immunology* Salmonella Infections/immunology* Salmonella typhimurium/genetics Salmonella typhimurium/immunology* Substances: Antibodies, Bacterial Antibodies, Blocking Bacterial Outer Membrane Proteins Immunoglobulin G Lipopolysaccharides O Antigens Grant Support: Biotechnology and Biological Sciences Research Council/United Kingdom Medical Research Council/United Kingdom Wellcome Trust/United Kingdom

2.	Science. 2010 Apr 23;328(5977):439-40. Immunology. Salmonella susceptibility. Moir S, Fauci AS. Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. smoir@niaid.nih.gov Comment on: Science. 2010 Apr 23;328(5977):508-12.
	PMID: 20413482 [PubMed - indexed for MEDLINE]
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	Publication Types: Comment MeSH Terms: AIDS-Related Opportunistic Infections/immunology Animals Antibodies, Bacterial/blood Antibodies, Bacterial/immunology* Antibodies, Blocking/blood Antibodies, Blocking/immunology* Bacteremia/immunology Bacterial Outer Membrane Proteins/immunology Disease Susceptibility HIV Infections/complications HIV Infections/immunology* Humans Lipopolysaccharides/blood Lipopolysaccharides/immunology* Mice Salmonella/immunology* Salmonella Infections/immunology* Substances: Antibodies, Bacterial Antibodies, Blocking Bacterial Outer Membrane Proteins Lipopolysaccharides