What's new for 'JKB_daily1' in PubMed

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Sender's message: Sepsis or genomics or altitude: JKB_daily1

Sent on Wednesday, 2010 May 19
Search (sepsis[MeSH Terms] OR septic shock[MeSH Terms] OR altitude[MeSH Terms] OR genomics[MeSH Terms] OR genetics[MeSH Terms] OR retrotransposons[MeSH Terms] OR macrophage[MeSH Terms]) AND ("2009/8/8"[Publication Date] : "3000"[Publication Date]) AND (("Science"[Journal] OR "Nature"[Journal] OR "The New England journal of medicine"[Journal] OR "Lancet"[Journal] OR "Nature genetics"[Journal] OR "Nature medicine"[Journal]) OR (Hume DA[Author] OR Baillie JK[Author] OR Faulkner, Geoffrey J[Author]))
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PubMed Results

Items 1 - 3 of 3

1.	N Engl J Med. 2010 May 13;362(19):1804-13. Hospital-acquired infections due to gram-negative bacteria. Peleg AY, Hooper DC. Division of Infectious Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. apeleg@bidmc.harvard.edu
	PMID: 20463340 [PubMed - indexed for MEDLINE]
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	Publication Types: Review MeSH Terms: Anti-Bacterial Agents/therapeutic use* Bacteremia/drug therapy Cross Infection/drug therapy* Cross Infection/microbiology* Drug Resistance, Bacterial*/physiology Gram-Negative Bacteria*/isolation & purification Gram-Negative Bacteria*/physiology Gram-Negative Bacterial Infections/drug therapy* Humans Pneumonia, Bacterial/drug therapy Risk Factors Urinary Tract Infections/drug therapy Substances: Anti-Bacterial Agents

2.	Science. 2010 May 7;328(5979):745-8. Cross-reacting antibodies enhance dengue virus infection in humans. Dejnirattisai W, Jumnainsong A, Onsirisakul N, Fitton P, Vasanawathana S, Limpitikul W, Puttikhunt C, Edwards C, Duangchinda T, Supasa S, Chawansuntati K, Malasit P, Mongkolsapaya J, Screaton G. Department of Medicine, Imperial College London, London W12 0NN, UK. Abstract Dengue virus co-circulates as four serotypes, and sequential infections with more than one serotype are common. One hypothesis for the increased severity seen in secondary infections is antibody-dependent enhancement (ADE) leading to increased replication in Fc receptor-bearing cells. In this study, we have generated a panel of human monoclonal antibodies to dengue virus. Antibodies to the structural precursor-membrane protein (prM) form a major component of the response. These antibodies are highly cross-reactive among the dengue virus serotypes and, even at high concentrations, do not neutralize infection but potently promote ADE. We propose that the partial cleavage of prM from the viral surface reduces the density of antigen available for viral neutralization, leaving dengue viruses susceptible to ADE by antibody to prM, a finding that has implications for future vaccine design.
	PMID: 20448183 [PubMed - indexed for MEDLINE]
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	Publication Types: Research Support, Non-U.S. Gov't MeSH Terms: Aedes Animals Antibodies, Monoclonal/immunology Antibodies, Neutralizing/immunology Antibodies, Viral/immunology* Antibody-Dependent Enhancement* Antigens, Viral/immunology* Cell Line Cross Reactions Dengue/immunology* Dengue Vaccines/immunology Dengue Virus/classification Dengue Virus/immunology* Dengue Virus/physiology Encephalitis Virus, Japanese/immunology Humans Immune Evasion Monocytes/immunology Monocytes/virology Receptors, Fc/immunology Serotyping U937 Cells Viral Envelope Proteins/immunology Viral Matrix Proteins/immunology* Viral Matrix Proteins/metabolism Virus Replication Substances: Antibodies, Monoclonal Antibodies, Neutralizing Antibodies, Viral Antigens, Viral Dengue Vaccines Receptors, Fc Viral Envelope Proteins Viral Matrix Proteins Grant Support: Medical Research Council/United Kingdom Wellcome Trust/United Kingdom

3.	Science. 2010 May 7;328(5979):697-8. Immunology. Tumor immune evasion. Zindl CL, Chaplin DD. Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Comment on: Science. 2010 May 7;328(5979):749-52.
	PMID: 20448171 [PubMed - indexed for MEDLINE]
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	Publication Types: Comment MeSH Terms: Animals Antigen-Presenting Cells/immunology B-Lymphocytes/immunology Chemokine CCL21/metabolism Cytokines/metabolism Humans Immune Tolerance Lymphoid Tissue/immunology* Lymphoid Tissue/pathology* Macrophages/immunology Melanoma/immunology* Melanoma/pathology* Mice Stromal Cells/immunology Stromal Cells/pathology T-Lymphocytes/immunology Tumor Escape* Substances: CCL21 protein, human Chemokine CCL21 Cytokines