What's new for 'JKB_daily1' in PubMed

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Sender's message: Sepsis or genomics or altitude: JKB_daily1

Sent on Friday, 2014 December 19
Search: (sepsis[MeSH Terms] OR septic shock[MeSH Terms] OR altitude[MeSH Terms] OR genomics[MeSH Terms] OR genetics[MeSH Terms] OR retrotransposons[MeSH Terms] OR macrophage[MeSH Terms]) AND ("2009/8/8"[Publication Date] : "3000"[Publication Date]) AND (("Science"[Journal] OR "Nature"[Journal] OR "The New England journal of medicine"[Journal] OR "Lancet"[Journal] OR "Nature genetics"[Journal] OR "Nature medicine"[Journal]) OR (Hume DA[Author] OR Baillie JK[Author] OR Faulkner, Geoffrey J[Author]))

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PubMed Results

Item 1 of 1

1.	Science. 2014 Nov 21;346(6212):1000-3. doi: 10.1126/science.1261754. Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity. Fowler BJ1, Gelfand BD2, Kim Y3, Kerur N3, Tarallo V 4, Hirano Y3, Amarnath S5, Fowler DH5, Radwan M6, Young MT6, Pittman K7, Kubes P7, Agarwal HK8, Parang K8, Hinton DR9, Bastos-Carvalho A3, Li S3, Yasuma T3, Mizutani T3, Yasuma R3, Wright C3, Ambati J10. Abstract Nucleoside reverse transcriptase inhibitors (NRTIs) are mainstay therapeutics for HIV that block retrovirus replication. Alu (an endogenous retroelement that also requires reverse transcriptase for its life cycle)-derived RNAs activate P2X7 and the NLRP3 inflammasome to cause cell death of the retinal pigment epithelium in geographic atrophy, a type of age-related macular degeneration. We found that NRTIs inhibit P2X7-mediated NLRP3 inflammasome activation independent of reverse transcriptase inhibition. Multiple approved and clinically relevant NRTIs prevented caspase-1 activation, the effector of the NLRP3 inflammasome, induced by Alu RNA. NRTIs were efficacious in mouse models of geographic atrophy, choroidal neovascularization, graft-versus-host disease, and sterile liver inflammation. Our findings suggest that NRTIs are ripe for drug repurposing in P2X7-driven diseases. Copyright © 2014, American Association for the Advancement of Science.
	PMID: 25414314 [PubMed - indexed for MEDLINE]